Allele Dmel\Cp190¹

General Information
Symbol	Dmel\Cp190¹	Species	D. melanogaster
Name		FlyBase ID	FBal0191421
Feature type	allele	Associated gene	Dmel\Cp190

Allele class	loss of function allele
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	loss of function allele (Butcher et al., 2004)
Mutagen	ethyl methanesulfonate (Butcher et al., 2004)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| larval stage \| partially (with Cp190²) (Butcher et al., 2004) lethal \| larval stage \| partially (with Df(3R)P280-NR27) (Butcher et al., 2004) lethal \| larval stage \| partially \| recessive (Butcher et al., 2004) lethal \| pharate adult stage (with Cp190²) (Butcher et al., 2004) lethal \| pharate adult stage (with Df(3R)P280-NR27) (Butcher et al., 2004) lethal \| pharate adult stage \| recessive (Butcher et al., 2004)
Phenotype Manifest In

Detailed Description
	Statement Reference Cp190¹, Cp190¹/Df(3R)P280-NR27 and Cp190¹/Cp190² mutants show some larval mortality, but approximately half the mutants survive until late pupal stages, dying as pharate adults. The eyes, wings and cuticle of Cp190¹ pharate adults appear normal, showing that tissue organization is not affected by a major defect in mitosis. Additionally, there are no observable meiotic defects in Cp190¹ larval testes. (Butcher et al., 2004)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Cp190[+]/Cp190¹ is a suppressor of visible phenotype of Fab-8^60.85.1 (Mohan et al., 2007)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference A single copy of Cp190[1] is sufficient to impair Fab-8[60.85.1] enhancer blocking (as shown by increased eye pigmentation). (Mohan et al., 2007)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	Cp190¹ is rescued by Cp190^Ubi-p63E.PB (Butcher et al., 2004) Df(3R)P280-NR27/Cp190¹ is rescued by Cp190^Ubi-p63E.PB (Butcher et al., 2004)
Partially rescued by	Cp190¹ is partially rescued by Cp190^ΔM.Ubi-p63E (Butcher et al., 2004)
Comments	The Cp190^ΔM.Ubi-p63E transgene rescues the lethality of Cp190¹ mutants so that ~80% of flies survive to adulthood. However, these adults are unhealthy and only survive for a few days. (Butcher et al., 2004)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Cp190¹ (Bartkuhn et al., 2009, Mohan et al., 2007)
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Bartkuhn et al., 2009, EMBO J. 28(7): 877--888 Active promoters and insulators are marked by the centrosomal protein 190. [FBrf0207850] Mohan et al., 2007, EMBO J. 26(19): 4203--4214 The Drosophila insulator proteins CTCF and CP190 link enhancer blocking to body patterning. [FBrf0200449] Chodagam et al., 2005, Curr. Biol. 15(14): 1308--1313 The centrosomal protein CP190 regulates myosin function during early Drosophila development. [FBrf0187303] Butcher et al., 2004, J. Cell Sci. 117(7): 1191--1199 The Drosophila centrosome-associated protein CP190 is essential for viability but not for cell division. [FBrf0174805]

Allele Dmel\Cp1901

Allele Dmel\Cp190¹