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General Information
Symbol
Dmel\dj-1βa
Species
D. melanogaster
Name
FlyBase ID
FBal0191459
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Local hopping of the P{EP} resulting in its insertion at base pair 178 of the dj-1β gene.

Insertion components
P{EP}dj-1βa
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

dj-1βa flies have the same amount of dopaminergic neurons as controls at 20 or 40 days old. However, at 60 days, the mutants show a higher number of dopaminergic neurons compared to controls. Dopaminergic cell clusters in PPL1, PPM1/2 and PPL2 regions of the brain survive better in dj-1βa mutants compared to other regions. However, despite the reduction in dopaminergic neuron loss, 60 day-old dj-1βa flies display sedentary behaviour similar to wild-type flies of the same age. dj-1βa flies, like wild-type flies, show no reduction in the amount of serotoninergic neurons between the ages of 10 and 60 days. dj-1βa flies show resistance to paraquat. However, these flies are more sensitive to H2O2 than wild-type flies.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
dj-1βa
Name Synonyms
Secondary FlyBase IDs
    References (2)