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General Information
Symbol
Dmel\TorA948V
Species
D. melanogaster
Name
FlyBase ID
FBal0191669
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C13008240T

Amino acid change:

A948V | Tor-PA; A949V | Tor-PB

Reported amino acid change:

A948V

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Mutation is within the HEAT-repeat domain of the Tor protein.

Amino acid replacement: A948V.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

5-15% of TorA948V mutants are able to survive to adulthood. These escapers are about half the size of wild type and are developmentally delayed by 2 days at 25oC. Escaper flies are 10:1 female:male and both genders are sterile. Ovaries dissected from TorA948V females display arrested development and increased cell death at a previtellogenic stage. Testes are abnormal and have a grossly enlarged apical tip.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

Tor[+]/TorA948V is a suppressor | partially of lethal | larval stage phenotype of gig193/gig109

Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The partial lethality of either Nprl21 or Nprl31 single mutants can be significantly suppressed by combination with a single copy of TorA948V.

Around 45% of TorA948V/+; gig109/gig193 flies survive to adulthood, while no gig109/gig193 survive to the pupal stage.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Selected as: a mutation that is lethal in trans to the TorΔP deletion.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)