|Feature type||allele||Associated gene||Dmel\tkv|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Phenotype Manifest In|
dorsal mesothoracic disc & actin filament | somatic clone
dorsal mesothoracic disc & microtubule | apical | somatic clone
leg & adult cuticle | somatic clone
wing & adult cuticle | somatic clone
Homozygous clones in medial regions of the wing disc epithelium show defects in their ability to establish or maintain the pseudostratified columnar cell shape, resulting in their retraction from the apical epithelial surface and subsequent basal extrusion as inverted epithelial cysts. Fewer mutant clones are recovered compared to their twin spot controls in the presumptive medial blade territory, suggesting that some mutant clones undergo cell death. A large number of extruding clones are recovered in the presumptive hinge and notum regions, with a fraction of these extending apically rather than basally. Apical microtubule arrays are eliminated cell-autonomously in homozygous clones in the wing disc, while basal microtubule networks are unaffected. The cells also show a subtle but consistent reduction of F-actin at the basolateral cortex of cells on the clone interior, transient ectopic accumulation of F-actin at the apical adherens junctions and ectopic accumulation of F-actin at boundaries between mutant cells and their wild-type neighbours. Many homozygous clones survive metamorphosis, forming differentiated inverted cuticular vesicles lodged between the dorsal and ventral surfaces of the adult wing or leg.
|Phenotype Manifest In|
|NOT suppressed by|
|Complementation & Rescue Data|
|Fails to complement|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 3 )|
|Secondary FlyBase IDs|
|References ( 2 )|