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General Information
Symbol
Dmel\tkvxtr
Species
D. melanogaster
Name
extruded
FlyBase ID
FBal0191914
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

dorsal mesothoracic disc & actin filament | somatic clone

dorsal mesothoracic disc & microtubule | apical | somatic clone

leg & adult cuticle | somatic clone

wing & adult cuticle | somatic clone

Detailed Description
Statement
Reference

Homozygous clones in medial regions of the wing disc epithelium show defects in their ability to establish or maintain the pseudostratified columnar cell shape, resulting in their retraction from the apical epithelial surface and subsequent basal extrusion as inverted epithelial cysts. Fewer mutant clones are recovered compared to their twin spot controls in the presumptive medial blade territory, suggesting that some mutant clones undergo cell death. A large number of extruding clones are recovered in the presumptive hinge and notum regions, with a fraction of these extending apically rather than basally. Apical microtubule arrays are eliminated cell-autonomously in homozygous clones in the wing disc, while basal microtubule networks are unaffected. The cells also show a subtle but consistent reduction of F-actin at the basolateral cortex of cells on the clone interior, transient ectopic accumulation of F-actin at the apical adherens junctions and ectopic accumulation of F-actin at boundaries between mutant cells and their wild-type neighbours. Many homozygous clones survive metamorphosis, forming differentiated inverted cuticular vesicles lodged between the dorsal and ventral surfaces of the adult wing or leg.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT suppressed by
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Expression of BacA\p35Scer\UAS.cHa under the control of Scer\GAL4T155 does not rescue the extrusion of tkvxtr clones from the wing disc.

Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)