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General Information
Symbol
Dmel\LamCEX187
Species
D. melanogaster
Name
FlyBase ID
FBal0192072
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference
Imprecise excision of the P{PTT-GB} element, resulting in a 357bp deletion in the first LamC exon. 2 insertions appear to be present (Avic\GFP sequences from the P{PTT-GB} element are detected but functional w[+] sequences are not present). The lesion is located within both the LamC and ttv transcription units (since LamC is nested within an intron of ttv). However, only LamC function is affected by the lesion, since the "EX187" chromosome complements ttv00681b and fails to complement LamCEP2199.
Insertion components
P{?PTT-GB}LamCEX187
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Many homozygotes raised on sterilised corn-meal medium at 24[o]C and places on sterilised 20% agar plates at the pre-pupal stage can survive to the late pupal stage. Adult body formation is seen within the pupal cases, but none complete head eversion and no adults eclose.
LamCEX187 is early larval lethal when homozygous and late larval lethal or early pupal lethal when hemizygous with Df(2R)trix. Heterozygous LamCEX187 suppresses the position effect variegation of P{hsp26-pt-T}39C-72. Heterozygous LamCEX187 suppresses the position effect variegation of T(2;3)SbV.
LamCEX187 mutant larval salivary gland nuclei show clustering of the nuclear pores. 15% of larval imaginal disc nuclei show separation of the inner and outer nuclear membranes and large perforations in the nuclear envelope resulting in chromatin leakage. The larval body wall muscles show abnormally shaped nuclei.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
In(1)wm4h; Su(var)2055/LamCEX187 flies have nearly normal red eye colour with little evidence of variegation.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Lamin CEX187
Secondary FlyBase IDs
    References (4)