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General Information
Symbol
Dmel\Gr64eMB03533
Species
D. melanogaster
Name
FlyBase ID
FBal0192448
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Insertion components
    Mi{ET1}Gr64eMB03533
    Product class / Tool use(s)
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Gr64eMB03533 mutants exhibit a statistically significant reduction in the response to trehalose, melezitose, m-glucoside and glucose. However, responses to sucrose, maltose, maltotriose, fructose and glycerol are unaffected.

    Gr64eMB03533 mutants show a marked loss of preference for 30% beer against 5mM (as in wild-type).

    Gr64eMB03533 flies show a substantially reduced preference for yeast extract and fermented grape. The preference for ripe banana is indistinguishable from wild-type flies.

    Gr64eMB03533 mutant flies show virtually no response to 10% glycerol, whereas control flies show a strong response.

    Gr64eMB03533 flies have a responsive sugar neuron, as a stimulus of 100mM sucrose elicits a firing rate comparable to that in control flies.

    L-type sensilla in Gr64eMB03533 flies lack a response to 10% glycerol. In contrast, mean responses to sucrose, fructose and glucose are as in wild-type.

    Gr64eMB03533 flies show greatly reduced proboscis extension responses to glycerol. In feeding preference assays in which populations of flies are presented with 5mM sucrose against varying concentrations of glycerol, wild-type flies show strong preferences for 1% and 10% glycerol.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments

    Expression of Gr64eScer\UAS.cWa in sugar taste neurons (under the control of Scer\GAL4Gr5a.8.5) restores glycerol sensitivity, although only partial rescue is seen at a 1% glycerol concentration.

    Images (0)
    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (3)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (4)