FlyBase Allele Report: Dmel\Trap1[EY21851]

General Information

Symbol

Dmel\Trap1^EY21851

Species

D. melanogaster

Name

FlyBase ID

FBal0192657

Feature type

allele

Associated gene

Dmel\Trap1

Associated Insertion(s)

P{EPgy2}Trap1^EY21851

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Bellen, 2006.8.3)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}Trap1^EY21851

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:6,633,894..6,633,894 [+]

(Bellen, 2006.8.3)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by Pink1^B9

(Kim et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal oxidative stress response | adult stage | chemical conditional

(Kim et al., 2016)

fertile

(Kim et al., 2016)

viable

(Kim et al., 2016)

Phenotype Manifest In

Detailed Description

Statement

Reference

Trap1^EY21851/Trap1^EY21851 mutants show normal mitochondrial function and morphology in the indirect flight muscle and have a normal lifespan when reared on normal media, compared to revertant controls. When placed on medium containing paraquat or rotenone, Trap1^EY21851/Trap1^EY21851 male flies show significantly increased survival compared to revertant and wild type flies.

(Kim et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Trap1^EY21851 has abnormal oxidative stress response | adult stage | chemical conditional phenotype, suppressible by foxo²⁵/foxo²¹

(Kim et al., 2016)

Suppressor of

Statement

Reference

Trap1^EY21851/Trap1^EY21851 is a suppressor of abnormal oxidative stress response | adult stage | chemical conditional phenotype of Pink1^B9

(Kim et al., 2016)

Trap1^EY21851/Trap1^EY21851 is a suppressor | partially of visible phenotype of Pink1^B9

(Kim et al., 2016)

Trap1^EY21851/Trap1^EY21851 is a suppressor of increased cell death | adult stage phenotype of Pink1^B9

(Kim et al., 2016)

Trap1^EY21851/Trap1^EY21851 is a suppressor | partially of abnormal locomotor behavior | adult stage phenotype of Pink1^B9

(Kim et al., 2016)

Trap1^EY21851/Trap1^EY21851 is a suppressor of abnormal neuroanatomy | adult stage phenotype of Pink1^B9

(Kim et al., 2016)

Other

Statement

Reference

Pink1^B9, Trap1^EY21851, foxo²¹/foxo[+] has abnormal locomotor behavior | adult stage phenotype

(Kim et al., 2016)

Phenotype Manifest In

Suppressor of

Statement

Reference

Trap1^EY21851/Trap1^EY21851 is a suppressor of dopaminergic PPL1 neuron | adult stage phenotype of Pink1^B9

(Kim et al., 2016)

Trap1^EY21851/Trap1^EY21851 is a suppressor of dopaminergic PPM2 neuron | adult stage phenotype of Pink1^B9

(Kim et al., 2016)

Trap1^EY21851/Trap1^EY21851 is a suppressor | partially of mesonotum phenotype of Pink1^B9

(Kim et al., 2016)

Trap1^EY21851/Trap1^EY21851 is a suppressor | partially of wing phenotype of Pink1^B9

(Kim et al., 2016)

Trap1^EY21851/Trap1^EY21851 is a suppressor of indirect flight muscle cell phenotype of Pink1^B9

(Kim et al., 2016)

Trap1^EY21851/Trap1^EY21851 is a suppressor | partially of mitochondrion | adult stage phenotype of Pink1^B9

(Kim et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Presence of Trap1^EY21851/Trap1^EY21851 significantly suppresses decreased survival in response to rotenone, crushed thorax and downturned wing phenotypes, cell death and disrupted mitochondrial function, and locomotor defects seen in Pink1^B9/Pink1^B9 flies. Trap1^D6/Trap1^D6 or Trap1^EY21851/Trap1^EY21851 significantly suppress dopamine neuron (DL1 and DM) loss in Pink1^B9/Pink1^B9 30 day old flies.

Presence of foxo²⁵/foxo²¹ significantly suppresses increased survival in response to rotenone or paraquat in Trap1^EY21851/Trap1^EY21851 flies.

foxo²¹/+ partially suppresses rescue of locomotor defects by Trap1^EY21851/Trap1^EY21851 in Pink1^B9/Pink1^B9 flies.

(Kim et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

22514

y¹ w^67c23; P{EPgy2}Trap1^EY21851

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

TRAP1^EY21851

(Kim et al., 2016)

TRAP1^P

(Kim et al., 2016)

Trap1^EY21851

(Bellen, 2006.8.3)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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