Allele Scer\GAL4^{Act5C.Switch.PR}

General Information
Symbol	Scer\GAL4^{Act5C.Switch.PR}	Species	S. cerevisiae
Name		FlyBase ID	FBal0192970
Feature type	allele	Associated gene	Scer\GAL4

Allele class
Mutagen	FLPase
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	FLPase (Rogulja and Irvine, 2005)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	Scer\GAL4^{Scer\FRT.Act5C.Switch.PR} (Rogulja and Irvine, 2005)
Nature of the lesion	Statement Reference
Carried in construct	P{Act5C(-FRT)GAL4.Switch.PR} (Rogulja and Irvine, 2005, Zhang et al., 2010, Ren et al., 2009, Ford et al., 2007, Zid et al., 2009, Baumgartner et al., 2010, Kallio et al., 2010, Wang et al., 2010, Wigby et al., 2011, Shen et al., 2009, Alic et al., 2011, Paik et al., 2012)
Cytology
Phenotypic Data
Phenotypic Class
	aging defective, with CoVb^GD6659 (Zid et al., 2009) aging defective, with l(3)neo18^GD3876 (Zid et al., 2009) immune response defective \| RU486 conditional, with Atg5^{dsRNA.Scer\UAS} (Ren et al., 2009) immune response defective \| RU486 conditional, with Atg7^{dsRNA.Scer\UAS} (Ren et al., 2009) immune response defective \| RU486 conditional, with Atg12^{dsRNA.Scer\UAS} (Ren et al., 2009) increased cell death \| somatic clone \| RU486 conditional, with kibra^Scer\UAS.cBa (Baumgartner et al., 2010) increased cell number \| cell non-autonomous \| somatic clone \| third instar larval stage, with tkv^{DE-Q199D.Scer\UAS.T:Ivir\HA1} (Rogulja and Irvine, 2005) increased cell number \| cell non-autonomous \| somatic clone \| third instar larval stage, with tkv^{Q253D.Scer\UAS.cNc} (Rogulja and Irvine, 2005) increased cell number \| somatic clone \| third instar larval stage, with tkv^{DE-Q199D.Scer\UAS.T:Ivir\HA1} (Rogulja and Irvine, 2005) increased cell number \| somatic clone \| third instar larval stage, with tkv^{Q253D.Scer\UAS.cNc} (Rogulja and Irvine, 2005) lethal \| larval stage \| RU486 conditional, with Ras85D^V12.Scer\UAS (Shen et al., 2009) lethal \| larval stage \| RU486 conditional, with wg^{Scer\UAS.cHa.T:Ivir\HA1} (Shen et al., 2009) long lived \| female \| RU486 conditional, with p53^259H.GUS (Shen et al., 2009) long lived \| female limited \| RU486 conditional, with ImpL2^Scer\UAS.cHa (Alic et al., 2011) long lived \| RU486 conditional, with fabp^Scer\UAS.cLa (Lee et al., 2012) mating defective \| RU486 conditional, with InR^{K1409A.Scer\UAS} (Wigby et al., 2011) mitotic cell cycle defective \| cell non-autonomous \| somatic clone \| third instar larval stage, with tkv^{DE-Q199D.Scer\UAS.T:Ivir\HA1} (Rogulja and Irvine, 2005) mitotic cell cycle defective \| cell non-autonomous \| somatic clone \| third instar larval stage, with tkv^{Q253D.Scer\UAS.cNc} (Rogulja and Irvine, 2005) mitotic cell cycle defective \| somatic clone \| third instar larval stage, with tkv^{DE-Q199D.Scer\UAS.T:Ivir\HA1} (Rogulja and Irvine, 2005) mitotic cell cycle defective \| somatic clone \| third instar larval stage, with tkv^{Q253D.Scer\UAS.cNc} (Rogulja and Irvine, 2005) mitotic cell cycle defective \| third instar larval stage, with tkv^{Q253D.Scer\UAS.cNc} (Rogulja and Irvine, 2005) short lived, with ImpL2^s.Scer\UAS (Paik et al., 2012) short lived \| male limited, with MRG15^GD11902 (Zhang et al., 2010) short lived \| RU486 conditional, with BacA\p35^Scer\UAS.cHa (Shen et al., 2009) short lived \| RU486 conditional, with Ras85D^V12.Scer\UAS (Shen et al., 2009) short lived \| RU486 conditional, with wg^{Scer\UAS.cHa.T:Ivir\HA1} (Shen et al., 2009) stress response defective, with CoVb^GD6659 (Zid et al., 2009) stress response defective, with l(3)neo18^GD3876 (Zid et al., 2009) stress response defective \| female limited \| RU486 conditional, with ImpL2^Scer\UAS.cHa (Alic et al., 2011) stress response defective \| RU486 conditional, with et^GD6535 (Kallio et al., 2010) stress response defective \| RU486 conditional, with et^KK105015 (Kallio et al., 2010) stress response defective \| RU486 conditional, with Stat92E^GD4492 (Kallio et al., 2010)
Phenotype Manifest In
	wing disc \| cell non-autonomous \| somatic clone \| third instar larval stage, with tkv^{DE-Q199D.Scer\UAS.T:Ivir\HA1} (Rogulja and Irvine, 2005) wing disc \| cell non-autonomous \| somatic clone \| third instar larval stage, with tkv^{Q253D.Scer\UAS.cNc} (Rogulja and Irvine, 2005) wing disc \| somatic clone \| RU486 conditional, with kibra^Scer\UAS.cBa (Baumgartner et al., 2010) wing disc \| somatic clone \| third instar larval stage, with tkv^{DE-Q199D.Scer\UAS.T:Ivir\HA1} (Rogulja and Irvine, 2005) wing disc \| somatic clone \| third instar larval stage, with tkv^{Q253D.Scer\UAS.cNc} (Rogulja and Irvine, 2005) wing disc \| third instar larval stage, with tkv^{Q253D.Scer\UAS.cNc} (Rogulja and Irvine, 2005)
Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference Scer\GAL4^{Act5C.Switch.PR}/Hsc70-4^Scer\UAS.cEa is an enhancer \| RU486 conditional of bang sensitive phenotype of Tpi^sgk-1/Tpi^sgk-1 (Hrizo and Palladino, 2010)
Suppressor of
Statement Reference Scer\GAL4^{Act5C.Switch.PR}/Hsc70-4^{K71S.Scer\UAS} is a suppressor \| RU486 conditional of bang sensitive phenotype of Tpi^sgk-1/Tpi^sgk-1 (Hrizo and Palladino, 2010)
NOT Suppressor of
Statement Reference Scer\GAL4^{Act5C.Switch.PR}/BacA\p35^Scer\UAS.cHa is a non-suppressor of increased cell number \| somatic clone \| cell non-autonomous \| third instar larval stage phenotype of tkv^{Q253D.Scer\UAS.cNc} (Rogulja and Irvine, 2005) Scer\GAL4^{Act5C.Switch.PR}/BacA\p35^Scer\UAS.cHa is a non-suppressor of increased cell number \| somatic clone \| third instar larval stage phenotype of tkv^{Q253D.Scer\UAS.cNc} (Rogulja and Irvine, 2005)
Phenotype Manifest In
NOT Suppressor of
Statement Reference Scer\GAL4^{Act5C.Switch.PR}/BacA\p35^Scer\UAS.cHa is a non-suppressor of wing disc \| somatic clone \| cell non-autonomous \| third instar larval stage phenotype of tkv^{Q253D.Scer\UAS.cNc} (Rogulja and Irvine, 2005) Scer\GAL4^{Act5C.Switch.PR}/BacA\p35^Scer\UAS.cHa is a non-suppressor of wing disc \| somatic clone \| third instar larval stage phenotype of tkv^{Q253D.Scer\UAS.cNc} (Rogulja and Irvine, 2005)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
Bloomington	9431 P{hsFLP}22, y¹ w^*; P{UAS-GFP.S65T}Myo31DF^T2; P{Act5C(-FRT)GAL4.Switch.PR}3/TM6B, Tb¹
Notes on Origin
Discoverer

Comments
	P{Act5C(-FRT)GAL4.Switch.PR}3 is reported as a stock (i.e.- germ-line transmitted), rather than just as somatic clones. (Rogulja and Irvine, 2005)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Scer\GAL4^{Act5C.Switch.PR}
Name Synonym
Secondary FlyBase IDs

References ( 14 )
Research paper	Lee et al., 2012, Oxid. Med. Cell. Longev. 2012: 854502 Overexpression of Fatty-Acid-β-Oxidation-Related Genes Extends the Lifespan of Drosophila melanogaster. [FBrf0219491] Paik et al., 2012, Mech. Ageing Dev. 133(5): 234--245 Misexpression screen delineates novel genes controlling Drosophila lifespan. [FBrf0218389] Alic et al., 2011, Aging Cell 10(1): 137--147 Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor. [FBrf0212768] Wigby et al., 2011, Proc. Biol. Sci. 278(1704): 424--431 Insulin signalling regulates remating in female Drosophila. [FBrf0212666] Hrizo and Palladino, 2010, Neurobiol. Disease 40(3): 676--683 Hsp70- and Hsp90-mediated proteasomal degradation underlies TPI(sugarkill) pathogenesis in Drosophila. [FBrf0212050] Kallio et al., 2010, FASEB J. 24(11): 4467--4479 Eye transformer is a negative regulator of Drosophila JAK/STAT signaling. [FBrf0212202] Wang et al., 2010, J. Mol. Cell. Biol. 2(3): 128--138 20-hydroxyecdysone reduces insect food consumption resulting in fat body lipolysis during molting and pupation. [FBrf0210866] Zhang et al., 2010, Exp. Gerontol. 45(11): 825--833 Conditional inactivation of MRG15 gene function limits survival during larval and adult stages of Drosophila melanogaster. [FBrf0212068] Ren et al., 2009, Exp. Gerontol. 44(3): 228--235 Conditional inhibition of autophagy genes in adult Drosophila impairs immunity without compromising longevity. [FBrf0206988] Shen et al., 2009, Aging 1(2): 191--211 A screen of apoptosis and senescence regulatory genes for life span effects when over-expressed in Drosophila. [FBrf0209964] Zid et al., 2009, Cell 139(1): 149--160 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. [FBrf0209084] Ford et al., 2007, Exp. Gerontol. 42(6): 483--497 Alteration of Drosophila life span using conditional, tissue-specific expression of transgenes triggered by doxycyline or RU486/Mifepristone. [FBrf0200753] Rogulja and Irvine, 2005, Cell 123(3): 449--461 Regulation of cell proliferation by a morphogen gradient. [FBrf0189921]
Supplementary material	Baumgartner et al., 2010, Dev. Cell 18(2): Supplemental Information. [FBrf0211373]

Allele Scer\GAL4Act5C.Switch.PR

Allele Scer\GAL4^{Act5C.Switch.PR}