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General Information
Symbol
Dmel\Ppt1UAS.cKa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct of Korey
FlyBase ID
FBal0193173
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS:Ppt1, UAS-Ppt1
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of Ppt1.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Scer\GAL4GMR.PU-mediated expression of Ppt1Scer\UAS.cKa leads to a blackened ommatidia phenotype with variable expressivity.

Negative geotaxis is not altered in flies expressing Ppt1Scer\UAS.cKa via Scer\GAL4elav.PU.

Overexpression of Ppt1Scer\UAS.cKa under the control of Scer\GAL4GMR.PF produces a degeneration of the developing adult visual system.

Expression of Ppt1Scer\UAS.cKa under the control of Scer\GAL4elav.PLu causes a reduction in viability.

Expression of Ppt1Scer\UAS.cKa in the eye under the control of Scer\GAL4GMR.PF results in adult flies with smaller eyes, disrupted ommatidial number and spacing, and absence of some sensory bristles. Some ommatidia are black in colour. The number of rhabdomeres/ommatidia is reduced in these eyes. Photoreceptor neurons are highly vacuolised with rhabdomeres in various stages of degenerations.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
NOT Enhanced by
Suppressed by
Statement
Reference
NOT suppressed by
Phenotype Manifest In
Enhanced by
Statement
Reference

Ppt1UAS.cKa, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has eye phenotype, enhanceable by zip[+]/zip1

Ppt1UAS.cKa, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has eye phenotype, enhanceable by zip2/zip[+]

Ppt1UAS.cKa, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has eye phenotype, enhanceable by Imp[+]/Imp8

Ppt1UAS.cKa, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has eye phenotype, enhanceable by tsg2/tsg[+]

Ppt1UAS.cKa, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has eye phenotype, enhanceable by tsg[+]/tsg4

NOT Enhanced by
Suppressed by
Statement
Reference
NOT suppressed by
Additional Comments
Genetic Interactions
Statement
Reference

Negative geotaxis is not altered in flies expressing Ppt1Scer\UAS.cKa via Scer\GAL4elav.PU in a Cisd2G6528 background.

A Vps28k16503/+ background does not enhance or suppress the eye degeneration phenotype found upon expression of Ppt1Scer\UAS.cKa under the control of Scer\GAL4GMR.PF.

A foij8E8/+, foi16.33/+ or foi20.71/+ background enhances the visual system degeneration seen in Scer\GAL4GMR.PF, Ppt1Scer\UAS.cKa flies.

A Cskj1D8/+ or CskS017909/+ background enhances the visual system degeneration seen in Scer\GAL4GMR.PF, Ppt1Scer\UAS.cKa flies.

A smt304493/+ or smt3k06307/+ background suppresses the visual system degeneration seen in Scer\GAL4GMR.PF, Ppt1Scer\UAS.cKa flies.

zip02957/+, zip1/+ or zip2/+ backgrounds enhance the visual system degeneration seen in Scer\GAL4GMR.PF, Ppt1Scer\UAS.cKa flies.

A Imp8/+ or ImpG0072/+ background enhances the visual system degeneration seen in Scer\GAL4GMR.PF, Ppt1Scer\UAS.cKa flies.

A tsg2/+ or tsg4/+ background enhances the visual system degeneration seen in Scer\GAL4GMR.PF, Ppt1Scer\UAS.cKa flies.

Overexpression of saxA.Scer\UAS suppresses the adult visual system degeneration seen in Scer\GAL4GMR.PF, Ppt1Scer\UAS.cKa flies while overexpression of saxQ263D.Scer\UAS.T:Ivir\HA1 enhances it.

Overexression of gbbScer\UAS.cKa with Ppt1Scer\UAS.cKa, both under the control of Scer\GAL4GMR.PF suppresses the visual system degeneration seen upon Ppt1Scer\UAS.cKa expression alone.

Co-expression of shiScer\UAS.cSa and Ppt1Scer\UAS.cKa in the developing eye under the control of Scer\GAL4GMR.PF enhances the eye degeneration seen in Scer\GAL4GMR.PF, Ppt1Scer\UAS.cKa flies.

Xenogenetic Interactions
Statement
Reference

Co-expression of BacA\p35GMR.PH in animals expressing Ppt1Scer\UAS.cKa in the eye under the control of Scer\GAL4GMR.PF significantly reduces the rough eye defects.

Complementation and Rescue Data
Comments

Expression of Scer\GAL4elav.PU>Ppt1Scer\UAS.cKa rescues the spontaneous miniature excitatory junction potential (mini EJP) frequency and locomotory phenotypes observed in Df(1)446-20 mutants.

The accumulation of abnormal storage material seen in the brains of Df(1)446-20 homozygotes is completely suppressed by expression of Ppt1Scer\UAS.cKa under the control of Scer\GAL4elav.PLu.

The rough eye defects in flies expressing Ppt1Scer\UAS.cKa in the eye under the control of Scer\GAL4GMR.PF are suppressed in a Df(1)RA2 or Df(1)KA14 mutant background.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Ppt1Scer\UAS.cKa
Ppt1UAS.cKa
Name Synonyms
Saccharomyces cerevisiae UAS construct of Korey
Secondary FlyBase IDs
    References (7)