Allele Dmel\Ppt1^S77F

General Information
Symbol	Dmel\Ppt1^S77F	Species	D. melanogaster
Name		FlyBase ID	FBal0193175
Feature type	allele	Associated gene	Dmel\Ppt1

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Hickey et al., 2006)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: S77F. (Hickey et al., 2006)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective (with Df(1)446-20) (Hickey et al., 2006) neuroanatomy defective (with Ppt1^A179T) (Hickey et al., 2006) short lived (with Df(1)446-20) (Hickey et al., 2006) short lived (with Ppt1^A179T) (Hickey et al., 2006)
Phenotype Manifest In
	adult brain (with Df(1)446-20) (Hickey et al., 2006) adult brain (with Ppt1^A179T) (Hickey et al., 2006)
Detailed Description
	Statement Reference Ppt1^S77F/Df(1)446-20 and Ppt1^A179T/Ppt1^S77F flies accumulate abnormal storage material as laminar deposits in their brains. Ppt1^S77F/Df(1)446-20 and Ppt1^A179T/Ppt1^S77F flies have more abundant autofluorescent inclusions in the brain than control flies. The median lifespan of Ppt1^S77F/Df(1)446-20 and Ppt1^A179T/Ppt1^S77F flies is reduced 42 and 20% respectively compared to controls. The median lifespan of Ppt1^S77F hemizygotes is reduced 29% compared to controls. (Hickey et al., 2006)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
Bloomington	30879 w¹¹¹⁸ Ppt1^S77F
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Ppt1^S77F (Hickey et al., 2006, Saja et al., 2010)
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Saja et al., 2010, Neurobiol. Disease 40(1): 135--145 Identifying cellular pathways modulated by Drosophila palmitoyl-protein thioesterase 1 function. [FBrf0211567] Hickey et al., 2006, Genetics 172(4): 2379--2390 Palmitoyl-protein thioesterase 1 deficiency in Drosophila melanogaster causes accumulation of abnormal storage material and reduced life span. [FBrf0190728]

Allele Dmel\Ppt1S77F

Allele Dmel\Ppt1^S77F