Allele Dmel\Su(var)2-HP2^Q2543X

General Information
Symbol	Dmel\Su(var)2-HP2^Q2543X	Species	D. melanogaster
Name		FlyBase ID	FBal0193335
Feature type	allele	Associated gene	Dmel\Su(var)2-HP2

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Shaffer et al., 2006)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Position of amino acid replacement is with respect to accession NP_610972. (Shaffer et al., 2006) Amino acid replacement: Q2543@. (Shaffer et al., 2006) Nucleotide substitution: C?T. (Shaffer et al., 2006)
Cytology
Phenotypic Data
Phenotypic Class
	lethal (Shaffer et al., 2006) non-suppressor of variegation, with In(1)w^m4h (Shaffer et al., 2006)
Phenotype Manifest In
	condensed chromosome (with Df(2R)B11) (Shaffer et al., 2006)
Detailed Description
	Statement Reference Metaphases from Su(var)2-HP2^Q2543X/Df(2R)B11 larval brains show a number of abnormalities (frequency of cells showing each phenotype is indicated in parentheses), such as abnormal chromosome condensation (0.5%), hyperploid/polyploid cells (1.0%), chromosome breaks (0.5%) and precocious sister-chromatid segregation (1.0%). (Shaffer et al., 2006)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	E814 (Shaffer et al., 2006) Q2543X (Shaffer et al., 2006) Su(var)2-HP2^Q2543X
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Shaffer et al., 2006, Genetics 174(3): 1189--1204 The large isoform of Drosophila melanogaster heterochromatin protein 2 plays a critical role in gene silencing and chromosome structure. [FBrf0194370]

Allele Dmel\Su(var)2-HP2Q2543X

Allele Dmel\Su(var)2-HP2^Q2543X