The distribution and number of apoptotic cells is similar to that of control embryos in debclE26 BuffyH37 double mutant stage 11 and late stage 12 embryos. Stage 16 double mutant embryos have normal central and peripheral nervous system patterning and no fusion of commissural axon bundles is seen. Normal histolysis of the larval midgut occurs during pupation in the double mutant animals and larval salivary glands also undergo histolysis. Programmed cell death in the pupal retina also occurs normally to remove a subset of interommatidial cells. Programmed cell death in the arista is also normal in the double mutants.
The rough eye phenotype induced by expression of Hsap\BCL2L13Scer\UAS.cNa driven by Scer\GAL4GMR.PS is not significantly enhanced or suppressed by DebclE26 BuffyH37/+, DebclW105 BuffyH37/+ or BuffyH37/+ mutations. DebclE26 BuffyH37/+, DebclW105 BuffyH37/+ or BuffyH37/+ in Scer\GAL4GMR.PS>Hsap\BCL2L13ΔTM.Scer\UAS flies does not result in significant eye phenotypes.