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General Information
Symbol
Dmel\dysf2
Species
D. melanogaster
Name
FlyBase ID
FBal0193496
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dys2
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C26088238T

Reported nucleotide change:

C?T

Amino acid change:

Q151term | dysf-PB; Q187term | dysf-PC; Q187term | dysf-PD

Reported amino acid change:

Q187term

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: C?T.

Amino acid replacement: Q187term.

The premature stop codon is in the HLH region, resulting in a truncated 187 residue protein (as opposed to 917 residues), which lacks the PAS-1 and PAS-2 domains.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

dysf2/dysf3 escapers display a complete absence of tarsal joint formation with a small shortening of the tarsal region. No defects are observed in most proximal joints or in the tarsus/pretarsus joint. The joint between the a5 and the arista in the antenna is also lost.

The distribution of apoptotic cells in the dysf2/dysf3 mutant prepupal leg is altered compared to wild type.

The ganglionic branches, dorsal branches, and lateral trunk branches in dys2/dys3 mutant second instar larvae show a complete absence of fusion in all branches examined. The dorsal trunk is fused and relatively normal in appearance, although some dorsal trunk fusion sites are constricted. Penetrance and expressivity are 100%.

In dys2/dys3 stage 16 embryos the dorsal branches and lateral trunks fail to fuse, while the dorsal trunk is fused.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT suppressed by
Statement
Reference
NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

dysf2/dysf3 does not suppress the production of cuticle folds along the proximo-distal axis of the leg that resemble ectopic joints seen when Nint.G.Scer\UAS is expressed under the control of Scer\GAL4ptc.PU (and limited to the third instar larval stage using Scer\GAL80ts.αTub84B). As in dysf2/dysf3 mutants alone, endogenous tarsal joints are not formed.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (7)