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General Information
Symbol
Dmel\DarkD1292A.UAS.Tag:polyHis,Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0193515
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-darkV
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of Dark coding sequences, with a mutated caspase site (carries the amino acid replacement D1292A), with 8xTag:polyHis at the N-terminal end and 6xTag:MYC tags at the carboxy terminal end.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of ArkScer\UAS.T:Zzzz\His6,T:Hsap\MYC in hemocytes, under the control of Scer\GAL4Hml.PG almost completely restores apoptosis levels after Smac mimetic treatment.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Adult Ark82 flies rescued to viability by expression of ArkB1292A.Scer\UAS.T:Zzzz\His6,T:Hsap\MYC under the control of Scer\GAL4unspecified display split thorax phenotypes and bristle abnormalities in the notum.

Surprisingly, in the absence of any Scer\GAL4 driver, `leaky' expression of ArkB1292A.Scer\UAS.T:Zzzz\His6,T:Hsap\MYC partially rescues Ark82 lethality.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
ArkB1292A.Scer\UAS.T:Zzzz\His6,T:Hsap\MYC
DarkB1292A.Scer\UAS.T:Zzzz\His6,T:Hsap\MYC
DarkD1292A.UAS.Tag:polyHis,Tag:MYC
Name Synonyms
Secondary FlyBase IDs
    References (3)