FlyBase Allele Report: Dmel\ft[ΔECD.UAS]

General Information

Symbol

Dmel\ft^ΔECD.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0193591

Feature type

allele

Associated gene

Dmel\ft

Associated Insertion(s)

Carried in Construct

P{UAS-ft.ΔECD}

Also Known As

UAS-ftΔECD, UAS-ft^ΔECD

Allele class

Mutagen

in vitro construct - deletion

Nature of the Allele

Allele class

Mutagen

in vitro construct - deletion

(Matakatsu and Blair, 2006)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

ft^UAS.cMa

(Matakatsu and Blair, 2006)

Carried in construct

P{UAS-ft.ΔECD}

Cytology

Nature of the lesion

Statement

Reference

The ft coding fragment has an internal deletion, that starts at QPT137 and ends at C4569. This begins with the first cadherin domain and ends three amino acids into the transmembrane domain.

(Matakatsu and Blair, 2006)

Allele components

Product class / Tool use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

cell polarity defective, with Scer\GAL4^Act5C.PI

(Matakatsu and Blair, 2006)

hypoplasia, with Scer\GAL4^nub.PU

(Gaspar et al., 2015)

size defective, with Scer\GAL4^32B

(Poon et al., 2011)

visible, with Scer\GAL4^32B

(Poon et al., 2011)

visible | adult stage, with Scer\GAL4^nub.PU

(Gaspar et al., 2015)

Phenotype Manifest In

wing, with Scer\GAL4^32B

(Poon et al., 2011)

wing, with Scer\GAL4^Act5C.PI

(Matakatsu and Blair, 2006)

wing, with Scer\GAL4^nub-AC-62

(Willecke et al., 2006)

wing blade, with Scer\GAL4^nub.PU

(Gaspar et al., 2015)

Detailed Description

Statement

Reference

Ectopic expression of ft^{ΔECD.Scer\UAS} under the control of Scer\GAL4^nub.PU results in severely undergrown wings in adult flies.

(Gaspar et al., 2015)

Expression of ft^{ΔECD.Scer\UAS} under the control of Scer\GAL4^32B produces flies with reduced wing size compared to controls.

(Poon et al., 2011)

Expression of ft^{ΔECD.Scer\UAS} under the control of Scer\GAL4^Act5C.PI causes mild perturbation of planar cell polarity in the wing and a foreshortening along the proximodistal axis of the wing blade as the anterior and posterior crossveins are abnormally close.

(Matakatsu and Blair, 2006)

Overexpression of ft^{ΔECD.Scer\UAS} in the developing wing, under the control of Scer\GAL4^nub-AC-62 causes small and narrow wings.

(Willecke et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^nub.PU, ft^ΔECD.UAS has visible | adult stage phenotype, suppressible | partially by Scer\GAL4^nub.PU/Zyx^UAS.cGa

(Gaspar et al., 2015)

Scer\GAL4^nub.PU, ft^ΔECD.UAS has hypoplasia phenotype, suppressible | partially by Scer\GAL4^nub.PU/Zyx^UAS.cGa

(Gaspar et al., 2015)

Scer\GAL4^32B, ft^ΔECD.UAS has visible phenotype, suppressible by Tao⁵⁰

(Poon et al., 2011)

Scer\GAL4^32B, ft^ΔECD.UAS has size defective phenotype, suppressible by Tao⁵⁰

(Poon et al., 2011)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^nub.PU, ft^ΔECD.UAS has wing blade phenotype, suppressible | partially by Scer\GAL4^nub.PU/Zyx^UAS.cGa

(Gaspar et al., 2015)

Scer\GAL4^32B, ft^ΔECD.UAS has wing phenotype, suppressible by Tao⁵⁰

(Poon et al., 2011)

Scer\GAL4^nub-AC-62, ft^ΔECD.UAS has wing phenotype, suppressible by wts^x1/wts[+]

(Willecke et al., 2006)

Other

Statement

Reference

Scer\GAL4^Act5C.PI/Scer\GAL4^Act5C.PI, ds^ΔECD.UAS, ft^ΔECD.UAS has S2 cell-line phenotype

(Matakatsu and Blair, 2006)

Additional Comments

Genetic Interactions

Statement

Reference

The severely undergrown wing phenotype seen in adult flies expressing ft^{ΔECD.Scer\UAS} under the control of Scer\GAL4^nub.PU can be mildly alleviated by co-expression of Zyx^Scer\UAS.cGa.

(Gaspar et al., 2015)

Tao⁵⁰ suppresses the reduced wing size phenotype seen when ft^{ΔECD.Scer\UAS} is expressed under the control of Scer\GAL4^32B.

(Poon et al., 2011)

S2 cells that express with ds^{ΔECD.Scer\UAS} and ft^{ΔECD.Scer\UAS}, under the control of Scer\GAL4^Act5C.PI, fail to aggregate.

(Matakatsu and Blair, 2006)

The ft^{ΔECD.Scer\UAS} phenotype (under the control of Scer\GAL4^nub-AC-62) is suppressed by wts^x1 heterozygosity.

(Willecke et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

Scer\GAL4^en-e16E/ft^ΔECD.UAS partially rescues ft⁸/ft^G-rv

(Matakatsu and Blair, 2006)

Scer\GAL4^Act5C.PI, Scer\GAL4^Act5C.PI, ft^ΔECD.UAS partially rescues ft⁸/ft^G-rv

(Matakatsu and Blair, 2006)

Scer\GAL4^da.G32/ft^ΔECD.UAS partially rescues ft⁸/ft^G-rv

(Matakatsu and Blair, 2006)

Comments

Expression of ft^{ΔECD.Scer\UAS}, under the control of either Scer\GAL4^Act5C.PI or Scer\GAL4^da.G32, rescues the lethality of ft^G-rv/ft⁸ mutants and is effective in rescuing the wing disc overgrowth phenotype. Expression of ft^{ΔECD.Scer\UAS} in the posterior wing pouch, driven by Scer\GAL4^en-e16E, rescues the overgrowth phenotype of ft^G-rv/ft⁸ mutants in this region, but does not rescue overgrowth in the anterior. Expression of ft^{ΔECD.Scer\UAS} under the control of Scer\GAL4^Act5C.PI in ft^G-rv/ft⁸ mutants partially rescues the abdominal planar cell polarity defect.

(Matakatsu and Blair, 2006)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Carried in a plasmid and transfected into S2 cells for use in cell aggregation assays.

(Matakatsu and Blair, 2006)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ft^{ΔECD.Scer\UAS}

ft^ΔECD.UAS

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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