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General Information
Symbol
Dmel\ftΔECD.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0193591
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-ftΔECD, UAS-ftΔECD
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
The ft coding fragment has an internal deletion, that starts at QPT137 and ends at C4569. This begins with the first cadherin domain and ends three amino acids into the transmembrane domain.
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Ectopic expression of ftΔECD.Scer\UAS under the control of Scer\GAL4nub.PU results in severely undergrown wings in adult flies.
Expression of ftΔECD.Scer\UAS under the control of Scer\GAL432B produces flies with reduced wing size compared to controls.
Expression of ftΔECD.Scer\UAS under the control of Scer\GAL4Act5C.PI causes mild perturbation of planar cell polarity in the wing and a foreshortening along the proximodistal axis of the wing blade as the anterior and posterior crossveins are abnormally close.
Overexpression of ftΔECD.Scer\UAS in the developing wing, under the control of Scer\GAL4nub-AC-62 causes small and narrow wings.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference
The severely undergrown wing phenotype seen in adult flies expressing ftΔECD.Scer\UAS under the control of Scer\GAL4nub.PU can be mildly alleviated by co-expression of ZyxScer\UAS.cGa.
Tao50 suppresses the reduced wing size phenotype seen when ftΔECD.Scer\UAS is expressed under the control of Scer\GAL432B.
S2 cells that express with dsΔECD.Scer\UAS and ftΔECD.Scer\UAS, under the control of Scer\GAL4Act5C.PI, fail to aggregate.
The ftΔECD.Scer\UAS phenotype (under the control of Scer\GAL4nub-AC-62) is suppressed by wtsx1 heterozygosity.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Expression of ftΔECD.Scer\UAS, under the control of either Scer\GAL4Act5C.PI or Scer\GAL4da.G32, rescues the lethality of ftG-rv/ft8 mutants and is effective in rescuing the wing disc overgrowth phenotype. Expression of ftΔECD.Scer\UAS in the posterior wing pouch, driven by Scer\GAL4en-e16E, rescues the overgrowth phenotype of ftG-rv/ft8 mutants in this region, but does not rescue overgrowth in the anterior. Expression of ftΔECD.Scer\UAS under the control of Scer\GAL4Act5C.PI in ftG-rv/ft8 mutants partially rescues the abdominal planar cell polarity defect.
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments
Carried in a plasmid and transfected into S2 cells for use in cell aggregation assays.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
ftΔECD.Scer\UAS
ftΔECD.UAS
Name Synonyms
Secondary FlyBase IDs
    References (9)