Allele Dmel\ds^{ΔECD.Scer\UAS}

General Information
Symbol	Dmel\ds^{ΔECD.Scer\UAS}	Species	D. melanogaster
Name		FlyBase ID	FBal0193593
Feature type	allele	Associated gene	Dmel\ds

Allele class
Mutagen	in vitro construct - deletion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - deletion (Matakatsu and Blair, 2006)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	ds^Scer\UAS.cTa (Matakatsu and Blair, 2006)
Nature of the lesion	Statement Reference Internal deletion of the ds coding region from R143 to G3080 that removes the cadherin repeats and ends 17 amino acids from the predicted transmembrane domain. (Matakatsu and Blair, 2006)
Carried in construct	P{UAS-ds.ΔECD} (Matakatsu and Blair, 2006, Matakatsu and Blair, 2012)
Cytology
Phenotypic Data
Phenotypic Class
	lethal, with Scer\GAL4^αTub84B.PL, ds⁰⁵¹⁴² (Matakatsu and Blair, 2006) visible, with Scer\GAL4^hh-Gal4 (Matakatsu and Blair, 2012)
Phenotype Manifest In
	crossvein, with Scer\GAL4^en-e16E (Matakatsu and Blair, 2006) wing, with Scer\GAL4^en-e16E (Matakatsu and Blair, 2006) wing, with Scer\GAL4^hh-Gal4 (Matakatsu and Blair, 2012) wing, with Scer\GAL4^αTub84B.PL (Matakatsu and Blair, 2006) wing disc \| posterior compartment, with Scer\GAL4^hh-Gal4 (Matakatsu and Blair, 2012)
Detailed Description
	Statement Reference Expression of ds[ΔECD.Scer\UAS] under the control of Scer\GAL4[hh-Gal4] induces overgrowth of the posterior compartment in the wing disc and adult wing. (Matakatsu and Blair, 2012) Expression of ds^{ΔECD.Scer\UAS} in the wing does not affect planar cell polarity when driven by Scer\GAL4^salm-459.2, Scer\GAL4^Dll-md23, Scer\GAL4^ap-md544, Scer\GAL4^αTub84B.PL or Scer\GAL4^en-e16E. Wings that express ds^{ΔICD.Scer\UAS} under the control of Scer\GAL4^en-e16E causes a foreshortening along the proximodistal axis of the wing blade as the anterior and posterior crossveins are abnormally close and crossveins are partially missing. A mild version of this defect is observed when ds^{ΔECD.Scer\UAS} is driven by Scer\GAL4^αTub84B.PL. (Matakatsu and Blair, 2006)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Other
Statement Reference Scer\GAL4^Act5C.PI/Scer\GAL4^Act5C.PI, ds^{ΔECD.Scer\UAS}, ft^{ΔECD.Scer\UAS} has S2 cell-line phenotype (Matakatsu and Blair, 2006)
Additional Comments
Genetic Interactions
Statement Reference S2 cells that express with ds^{ΔECD.Scer\UAS} and ft^{ΔECD.Scer\UAS}, under the control of Scer\GAL4^Act5C.PI, fail to aggregate. (Matakatsu and Blair, 2006)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to rescue	ds^{ΔECD.Scer\UAS}/Scer\GAL4^ds-gal4 fails to rescue ds⁰⁵¹⁴² (Matakatsu and Blair, 2006)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Carried in a plasmid and transfected into S2 cells for use in cell aggregation assays. (Matakatsu and Blair, 2006)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	ds^{ΔECD.Scer\UAS}
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Matakatsu and Blair, 2012, Development 139(8): 1498--1508 Separating planar cell polarity and Hippo pathway activities of the protocadherins Fat and Dachsous. [FBrf0217773] Matakatsu and Blair, 2006, Development 133(12): 2315--2324 Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins. [FBrf0194700]

Allele Dmel\dsΔECD.Scer\UAS

Allele Dmel\ds^{ΔECD.Scer\UAS}