UASt regulatory sequences drive expression of a 70 nucleotide mir-6-1 microRNA that contains a 21bp fragment which is complementary to Dark coding regions in one strand of the mir-6-1 stem region.
decreased cell death | adult stage, with Scer\GAL4CCAP.PP
neuroanatomy defective | adult stage, with Scer\GAL4CCAP.PP
peptidergic neuron | adult stage | ectopic, with Scer\GAL4CCAP.PP
Expression of ArkmiRNA.Scer\UAS under the control of Scer\GAL4CCAP.PP strongly suppresses the programmed cell death of CCAP neurons in the adult ventral nerve cord after eclosion.
This construct is expected to produce a microRNA targeting the Ark gene.