Allele Dmel\cpa^107E

General Information
Symbol	Dmel\cpa^107E	Species	D. melanogaster
Name		FlyBase ID	FBal0193694
Feature type	allele	Associated gene	Dmel\cpa

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Janody and Treisman, 2006)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: ?162@. (Janody and Treisman, 2006)
Cytology
Phenotypic Data
Phenotypic Class
	cell lethal \| partially \| somatic clone (Janody and Treisman, 2006) lethal (Janody and Treisman, 2006) lethal (with cpa^43D) (Janody and Treisman, 2006)
Phenotype Manifest In
	eye, with Scer\GAL4^αTub84B.PL, cpa^{Scer\UAS.T:Ivir\HA1}/cpa^43D (Janody and Treisman, 2006) eye (with cpa^{Scer\UAS.T:Ivir\HA1}), with Scer\GAL4^αTub84B.PL, cpa^43D (Janody and Treisman, 2006, Janody and Treisman, 2006) macrochaeta, with Scer\GAL4^αTub84B.PL, cpa^{Scer\UAS.T:Ivir\HA1}/cpa^43D (Janody and Treisman, 2006) macrochaeta (with cpa^{Scer\UAS.T:Ivir\HA1}), with Scer\GAL4^αTub84B.PL, cpa^43D (Janody and Treisman, 2006, Janody and Treisman, 2006) wing, with Scer\GAL4^αTub84B.PL, cpa^{Scer\UAS.T:Ivir\HA1}/cpa^43D (Janody and Treisman, 2006) wing (with cpa^{Scer\UAS.T:Ivir\HA1}), with Scer\GAL4^αTub84B.PL, cpa^43D (Janody and Treisman, 2006, Janody and Treisman, 2006) wing disc \| somatic clone (Janody and Treisman, 2006, Fernández et al., 2011)
Detailed Description
	Statement Reference Homozygous clones in the wing disc are rounder than their wild-type twin spots. (Fernández et al., 2011) cpa^107E mutant clones induced at the first or second larval instar could not be recovered in the wing blade primordium, although mutant clones could develop in the remainder of the wing disc. Adults expressing cpa^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^αTub84B.PL in a cpa^43D/cpa^107E background sometimes show wing, eye or bristle defects. (Janody and Treisman, 2006)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement Reference cpa^107E has wing disc \| somatic clone phenotype, suppressible \| partially by Scer\GAL4^αTub84B.PL/th^Scer\UAS.cHa (Janody and Treisman, 2006)
Additional Comments
Genetic Interactions
Statement Reference Expression of th^Scer\UAS.cHa under the control of Scer\GAL4^αTub84B.PL enhances the survival of cpa^107E clones in the wing blade primordium. (Janody and Treisman, 2006)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	cpa^KG02261 (Janody and Treisman, 2006)
Partially rescued by	cpa^43D/cpa^107E is partially rescued by cpa^{Scer\UAS.T:Ivir\HA1}/Scer\GAL4^αTub84B.PL (Janody and Treisman, 2006) cpa^107E is partially rescued by cpa^{Scer\UAS.T:Ivir\HA1}/Scer\GAL4^αTub84B.PL (Janody and Treisman, 2006)
Comments	Expression of cpa^{Scer\UAS.T:Ivir\HA1} in the wing disc, under the control of Scer\GAL4^αTub84B.PL, prevents the extrusion of cpa^107E clones from the wing blade primordium. Ubiquitous expression of cpa^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^αTub84B.PL rescues the lethality of cpa^43D/cpa^107E mutants, although some of the rescued adults exhibit wing, eye or bristle defects. (Janody and Treisman, 2006)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	cpa^107E (Janody and Treisman, 2006, Fernández et al., 2011, Gates et al., 2009) cpa^1074E (Johnson et al., 2008)
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Fernández et al., 2011, Development 138(11): 2337--2346 Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. [FBrf0213674] Gates et al., 2009, Dev. Biol. 333(1): 90--107 Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis. [FBrf0208541] Johnson et al., 2008, J. Cell Biol. 180(6): 1191--1204 The Drosophila CD2AP/CIN85 orthologue Cindr regulates junctions and cytoskeleton dynamics during tissue patterning. [FBrf0204348] Janody and Treisman, 2006, Development 133(17): 3349--3357 Actin capping protein alpha maintains vestigial-expressing cells within the Drosophila wing disc epithelium. [FBrf0193788]

Allele Dmel\cpa107E

Allele Dmel\cpa^107E