FlyBase Allele Report: Dmel\Calx[B]

General Information

Symbol

Dmel\Calx^B

Species

D. melanogaster

Name

FlyBase ID

FBal0193745

Feature type

allele

Associated gene

Dmel\Calx

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Wang et al., 2005)

Progenitor genotype

Cytology

Description

There is no mutation in the coding region of Calx^B. There may be a mutation on a regulatory region.

(Wang et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Wang et al., 2005)

abnormal neurophysiology

(Wang et al., 2008, Wang et al., 2005)

short lived

(Mok et al., 2020)

short lived (with Calx^A)

(Mok et al., 2020)

uncoordinated | adult stage

(Akitake et al., 2015)

viable

(Wang et al., 2005)

Phenotype Manifest In

rhabdomere

(Wang et al., 2005)

Detailed Description

Statement

Reference

Mutant flies have a significantly reduced ability to successfully traverse large gaps of 3.5mm compared to

(Akitake et al., 2015)

A Calx^B mutant background partially suppresses the degeneration of photoreceptors found when Sk2^Scer\UAS.cYa is overexpressed in the developing eye under the control of Scer\GAL4^GMR.PF.

(Yonamine et al., 2011)

Mutant flies have an abnormal electroretinogram (ERG); the light response terminates more rapidly than in wild-type flies.

(Wang et al., 2008)

Mutant flies show degeneration of rhabdomeres; when maintained under a 12 hour light-12 hour dark cycle almost all rhabdomeres have degenerated by 14 days after eclosion.

(Wang et al., 2005)

Calx^B flies show a photoresponse inactivation phenotype.

(Wang et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Calx^B has uncoordinated | adult stage phenotype, suppressible by Trpγ¹

(Akitake et al., 2015)

Calx^B has abnormal neuroanatomy phenotype, suppressible by trp¹⁴

(Wang et al., 2005)

Calx^B has abnormal neuroanatomy phenotype, suppressible by trp⁹

(Wang et al., 2005)

Suppressor of

Statement

Reference

Calx^B is a suppressor | partially of abnormal neurophysiology | adult stage phenotype of Hsap\MAPT^{P301L.QUAS.0N4R}, Ncra\QF^QF2w.nSyb

(Praschberger et al., 2023)

Calx^B is a suppressor of uncoordinated | adult stage phenotype of Trpγ¹

(Akitake et al., 2015)

Calx^B is a suppressor of abnormal neuroanatomy phenotype of trp¹⁴

(Wang et al., 2005)

Calx^B is a suppressor of abnormal neuroanatomy phenotype of trp⁹

(Wang et al., 2005)

Phenotype Manifest In

Suppressed by

Statement

Reference

Calx^B has rhabdomere phenotype, suppressible by trp¹⁴

(Wang et al., 2005)

Calx^B has rhabdomere phenotype, suppressible by trp⁹

(Wang et al., 2005)

Suppressor of

Statement

Reference

Calx^B is a suppressor | partially of retina | adult stage phenotype of Hsap\MAPT^{P301L.QUAS.0N4R}, Ncra\QF^QF2w.nSyb

(Praschberger et al., 2023)

Calx^B is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PF, Sk2^UAS.cYa

(Yonamine et al., 2011)

Calx^B is a suppressor | partially of photoreceptor neuron phenotype of Scer\GAL4^GMR.PF, Sk2^UAS.cYa

(Yonamine et al., 2011)

Calx^B is a suppressor | partially of ommatidium phenotype of Scer\GAL4^GMR.PF, Sk2^UAS.cYa

(Yonamine et al., 2011)

Calx^B is a suppressor | partially of rhabdomere phenotype of Scer\GAL4^GMR.PF, Sk2^UAS.cYa

(Yonamine et al., 2011)

Calx^B is a suppressor of rhabdomere phenotype of trp¹⁴

(Wang et al., 2005)

Calx^B is a suppressor of rhabdomere phenotype of trp⁹

(Wang et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Double mutant Trpγ¹ ; Calx^B flies have a significantly less severe defect in their ability to successfully traverse large gaps of 3.5mm compared to either single mutant.

(Akitake et al., 2015)

Calx^B stops¹ double mutant flies show the slow electroretinogram termination phenotype seen in stops¹ single mutants.

(Wang et al., 2008)

The retinal degeneration seen in both Calx^B and trp¹⁴ single mutant flies when they are maintained under a 12 hour light-12 hour dark cycle is suppressed in Calx^B trp¹⁴ double mutants; most ommatidia in the double mutants contain the normal number of rhabdomeres at 14 days after eclosion.

The retinal degeneration seen in both Calx^B and trp⁹ single mutant flies when they are maintained under a 12 hour light-12 hour dark cycle is suppressed in Calx^B trp⁹ double mutants; most ommatidia in the double mutants contain the normal number of rhabdomeres at 14 days after eclosion.

(Wang et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Calx^E

(Wang et al., 2005)

Calx^D

(Wang et al., 2005)

Calx^C

(Wang et al., 2005)

Calx^A

(Wang et al., 2005)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

24497

w^*; Calx^B

Notes on Origin

Discoverer

Selected as: a homozygous viable mutation that disrupts the visual response.

(Wang et al., 2005)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Calx^B

(Praschberger et al., 2023, Mok et al., 2020)

calx^B

(Liu et al., 2020, Akitake et al., 2015, Chen et al., 2015, Yonamine et al., 2011, Wang et al., 2008, Wang et al., 2005, Wang et al., 2005)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

Open Close