Allele Dmel\Gr21a^Scer\UAS.cJa

General Information
Symbol	Dmel\Gr21a^Scer\UAS.cJa	Species	D. melanogaster
Name		FlyBase ID	FBal0193769
Feature type	allele	Associated gene	Dmel\Gr21a

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Jones et al., 2007)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of Gr21a. (Jones et al., 2007)
Carried in construct	P{UAS-Gr21a.J} (Jones et al., 2007, Ai et al., 2010)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference Expression of Gr21a^Scer\UAS.cJa under the control of Scer\GAL4^Or22a.7.717 does not confer CO₂ responsiveness onto ab3A neurons. (Jones et al., 2007)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Scer\GAL4^Ir64a.PA, Gr63a^Scer\UAS.cJa, Gr21a^Scer\UAS.cJa is a suppressor of smell perception defective \| recessive phenotype of Gr63a¹, Ir64a^MB05283 (Ai et al., 2010)
Phenotype Manifest In
Other
Statement Reference Gr21a^Scer\UAS.cJa, Gr63a^Scer\UAS.cJa, Scer\GAL4^Or22a.7.717 has abdominal 3 desA neuron phenotype (Jones et al., 2007)
Additional Comments
Genetic Interactions
Statement Reference Expression of both Gr63a[Scer\UAS.cJa] and Gr21a[Scer\UAS.cJa] under the control of Scer\GAL4[Ir64a.PA] in Ir64a[MB05283], Gr63a[1] double mutant flies allows artificial stimulation of DC4 dorsal glomeruli of the adult antennal lobe by 5% CO[[2]] and robust avoidance of CO[[2]] in behavioural experiments. However, DP1m neurons are not activated by CO[[2]] in these mutants. (Ai et al., 2010) Coexpression of Gr21a^Scer\UAS.cJa and Gr63a^Scer\UAS.cJa under the control of Scer\GAL4^Or22a.7.717 confers CO₂ responsiveness on ab3A neurons, a type of neuron that is normally unresponsive to CO₂. This is in contrast to expression of either UAS transgene alone or in combination with Gr10a^Scer\UAS.cJa, where CO₂ responsiveness is not conferred. (Jones et al., 2007)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
Bloomington	24615 w^*; Bl¹/CyO; P{UAS-Gr21a.J}124.7A
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Gr21a^Scer\UAS.cJa
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Ai et al., 2010, Nature 468(7324): 691--695 Acid sensing by the Drosophila olfactory system. [FBrf0212455] Jones et al., 2007, Nature 445(7123): 86--90 Two chemosensory receptors together mediate carbon dioxide detection in Drosophila. [FBrf0194189]

Allele Dmel\Gr21aScer\UAS.cJa

Allele Dmel\Gr21a^Scer\UAS.cJa