FlyBase Allele Report: Dmel\path[UAS.cGa]

General Information

Symbol

Dmel\path^UAS.cGa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Goberdhan

FlyBase ID

FBal0193813

Feature type

allele

Associated gene

Dmel\path

Associated Insertion(s)

Carried in Construct

P{UAS-path.G}

Key Links

Transgenic product class

wild_type

(Goberdhan et al., 2005)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Goberdhan et al., 2005)

Mutagen

in vitro construct

(Goberdhan et al., 2005)

Progenitor genotype

Carried in construct

P{UAS-path.G}

Cytology

Description

UASt sequences drive expression of full-length path.

(Goberdhan et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

path

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number, with Scer\GAL4^en-e16E

(Goberdhan et al., 2005)

decreased cell size, with Scer\GAL4^nub-AC-62

(Resnik-Docampo and de Celis, 2011)

increased cell number, with Scer\GAL4^nub-AC-62

(Resnik-Docampo and de Celis, 2011)

increased cell size, with Scer\GAL4^en-e16E

(Goberdhan et al., 2005)

Phenotype Manifest In

wing, with Scer\GAL4^en-e16E

(Goberdhan et al., 2005)

wing, with Scer\GAL4^nub-AC-62

(Resnik-Docampo and de Celis, 2011)

Detailed Description

Statement

Reference

Expression of path^Scer\UAS.cGa using Scer\GAL4^nub-AC-62 results in wings of normal size in which cell size is decreased and cell number is increased.

(Resnik-Docampo and de Celis, 2011)

path^Scer\UAS.cGa overexpression in the posterior wing compartment of the wing, driven by Scer\GAL4^en-e16E, produces an increase in cell size, even though wing area is reduced.

(Goberdhan et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^nub-AC-62, path^UAS.cGa has decreased cell size phenotype, enhanceable by Scer\GAL4^nub-AC-62/hppy^UAS.cMa

(Resnik-Docampo and de Celis, 2011)

Suppressed by

Statement

Reference

Scer\GAL4^nub-AC-62, path^UAS.cGa has increased cell number phenotype, suppressible by Scer\GAL4^nub-AC-62/hppy^UAS.cMa

(Resnik-Docampo and de Celis, 2011)

Enhancer of

Statement

Reference

path^UAS.cGa/Scer\GAL4^Bx-MS1096 is an enhancer of decreased cell number phenotype of Scer\GAL4^Bx-MS1096, mTor^{WT.UAS.Tag:FLAG}

(Goberdhan et al., 2005)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^nub-AC-62, path^UAS.cGa has wing phenotype, enhanceable by Scer\GAL4^nub-AC-62/hppy^UAS.cMa

(Resnik-Docampo and de Celis, 2011)

Suppressed by

Statement

Reference

Scer\GAL4^nub-AC-62, path^UAS.cGa has wing phenotype, suppressible by Scer\GAL4^nub-AC-62/hppy^UAS.cMa

(Resnik-Docampo and de Celis, 2011)

Enhancer of

Statement

Reference

path^UAS.cGa/Scer\GAL4^Bx-MS1096 is an enhancer of wing phenotype of Scer\GAL4^Bx-MS1096, mTor^{WT.UAS.Tag:FLAG}

(Goberdhan et al., 2005)

path^UAS.cGa, mTor^{WT.UAS.Tag:FLAG}, Scer\GAL4^GMR.PF is an enhancer of ommatidium phenotype of Scer\GAL4^GMR.PF, foxo^GS9928

(Goberdhan et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of hppy^Scer\UAS.cMa in the path^Scer\UAS.cGa, Scer\GAL4^nub-AC-62 background results in wings with cell sizes, cell numbers and overall wing size similar to hppy^Scer\UAS.cMa, Scer\GAL4^nub-AC-62 wings.

(Resnik-Docampo and de Celis, 2011)

path^Scer\UAS.cGa significantly enhances the reduced wing phenotype produced by overexpressing Tor^{WT.Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^Bx-MS1096.

Co-expression of path^Scer\UAS.cGa and Tor^{WT.Scer\UAS.T:Zzzz\FLAG} together enhance the Scer\GAL4^GMR.PF>foxo^GS9928 reduced eye phenotype.

(Goberdhan et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

path^UAS.cGa/Scer\GAL4^arm.PS partially rescues path^KG06640

(Goberdhan et al., 2005)

Comments

Expression of path^Scer\UAS.cGa under the control of the constitutive Scer\GAL4^arm.PS driver significantly rescues the growth, developmental delay and female sterility mutant phenotypes of path^KG06640 homozygotes. Rescued flies are slightly smaller than controls.

(Goberdhan et al., 2005)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

path^Scer\UAS.cGa

path^UAS.cGa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Goberdhan

Secondary FlyBase IDs

References (2)

Report Sections

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