Allele Dmel\wts^{Scer\UAS.X.T:Hsap\MYC}

General Information
Symbol	Dmel\wts^{Scer\UAS.X.T:Hsap\MYC}	Species	D. melanogaster
Name		FlyBase ID	FBal0193836
Feature type	allele	Associated gene	Dmel\wts

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - coding region fusion
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Mikeladze-Dvali et al., 2005) in vitro construct - regulatory fusion (Mikeladze-Dvali et al., 2005)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of wts, which is tagged with T:Hsap\MYC. (Mikeladze-Dvali et al., 2005)
Carried in construct	P{UAS-wts.X.MYC} (Mikeladze-Dvali et al., 2005, Sprecher et al., 2007)
Tagged with	T:Hsap\MYC (Mikeladze-Dvali et al., 2005)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	photoreceptor cell R8 of pale ommatidium, with Scer\GAL4^GMR.long (Mikeladze-Dvali et al., 2005) photoreceptor cell R8 of yellow ommatidium \| supernumerary, with Scer\GAL4^GMR.long (Mikeladze-Dvali et al., 2005)
Detailed Description
	Statement Reference The total number of photoreceptors, as well as the number of Rh5-positive and Rh6-positive photoreceptors is normal in the eyes of larvae expressing wts^{Scer\UAS.X.T:Hsap\MYC} under the control of Scer\GAL4^so-7.GAL4. (Sprecher et al., 2007) Expression of wts^{Scer\UAS.X.T:Hsap\MYC} in all photoreceptors, driven by Scer\GAL4^GMR.long, results in eyes that contain only yR8 photoreceptor cells and completely lack pR8 photoreceptor cells. The dorsal rim area R8 cells are not affected. (Mikeladze-Dvali et al., 2005)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
NOT suppressed by
Statement Reference Scer\GAL4^GMR.long, wts^{Scer\UAS.X.T:Hsap\MYC} has photoreceptor cell R8 of pale ommatidium phenotype, non-suppressible by melt^Scer\UAS.cTa/Scer\GAL4^GMR.long (Mikeladze-Dvali et al., 2005) Scer\GAL4^GMR.long, wts^{Scer\UAS.X.T:Hsap\MYC} has photoreceptor cell R8 of yellow ommatidium \| supernumerary phenotype, non-suppressible by melt^Scer\UAS.cTa/Scer\GAL4^GMR.long (Mikeladze-Dvali et al., 2005)
Additional Comments
Genetic Interactions
Statement Reference Coexpression of both wts^{Scer\UAS.X.T:Hsap\MYC} and melt^Scer\UAS.cTa, under the control of Scer\GAL4^GMR.long results in eyes with only yR8 photoreceptor cells and no pR8 photoreceptor cells, like eyes that express only wts^{Scer\UAS.X.T:Hsap\MYC}. However, the eyes expressing both transgenes contain some R8 cells that express both Rh6 and Rh5, indicative of both p and y fates. (Mikeladze-Dvali et al., 2005)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer	T. Xu

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	wts^{Scer\UAS.X.T:Hsap\MYC}
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Sprecher et al., 2007, Genes Dev. 21(17): 2182--2195 Adult and larval photoreceptors use different mechanisms to specify the same Rhodopsin fates. [FBrf0205916] Mikeladze-Dvali et al., 2005, Cell 122(5): 775--787 The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors. [FBrf0187233]

Allele Dmel\wtsScer\UAS.X.T:Hsap\MYC

Allele Dmel\wts^{Scer\UAS.X.T:Hsap\MYC}