Allele Dmel\melt^Scer\UAS.cTa

General Information
Symbol	Dmel\melt^Scer\UAS.cTa	Species	D. melanogaster
Name	Saccharomyces cerevisiae UAS construct a of Teleman	FlyBase ID	FBal0193838
Feature type	allele	Associated gene	Dmel\melt

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Teleman et al., 2005)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Expression of full length melt cDNA is under the control of Scer\UAS sequences. (Teleman et al., 2005)
Carried in construct	P{UAS-melt.T} (Teleman et al., 2005, Mikeladze-Dvali et al., 2005, Sprecher et al., 2007, McDonald et al., 2010, Terrell et al., 2012)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	photoreceptor cell R8 of pale ommatidium \| supernumerary, with Scer\GAL4^GMR.long (Mikeladze-Dvali et al., 2005) photoreceptor cell R8 of pale ommatidium \| supernumerary, with Scer\GAL4^Rh5.PT, Scer\GAL4^Rh6.PD (Mikeladze-Dvali et al., 2005)
Detailed Description
	Statement Reference The total number of photoreceptors, as well as the number of Rh5-positive and Rh6-positive photoreceptors is normal in the eyes of larvae expressing melt^Scer\UAS.cTa under the control of Scer\GAL4^so-7.GAL4. (Sprecher et al., 2007) Expression of melt^Scer\UAS.cTa in all photoreceptors, driven by Scer\GAL4^GMR.long, causes R8 photoreceptors to adopt a p fate. The dorsal rim area R8 cells are not affected. Expression of melt^Scer\UAS.cTa, under the control of Scer\GAL4^Rh5.PT and Scer\GAL4^Rh6.PD in R8 photoreceptor cells, increases the number of cells that adopt an R8 fate and causes ~63% of cells to express both Rh5 and Rh6, which are indicative of both p and y fates. Expression of this transgene in R7 photoreceptor cells, driven by Scer\GAL4^Rh3.PP and Scer\GAL4^Rh4.PT, does not affect the fate specification of R8 cells. (Mikeladze-Dvali et al., 2005)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement Reference melt^Scer\UAS.cTa/Scer\GAL4^GMR.long is a suppressor of photoreceptor cell R8 of pale ommatidium phenotype of sev¹⁴ (Mikeladze-Dvali et al., 2005)
NOT Suppressor of
Statement Reference melt^Scer\UAS.cTa/Scer\GAL4^GMR.long is a non-suppressor of photoreceptor cell R8 of pale ommatidium phenotype of Scer\GAL4^GMR.long, wts^{Scer\UAS.X.T:Hsap\MYC} (Mikeladze-Dvali et al., 2005) melt^Scer\UAS.cTa/Scer\GAL4^GMR.long is a non-suppressor of photoreceptor cell R8 of yellow ommatidium \| supernumerary phenotype of Scer\GAL4^GMR.long, wts^{Scer\UAS.X.T:Hsap\MYC} (Mikeladze-Dvali et al., 2005)
Additional Comments
Genetic Interactions
Statement Reference Eyes that express melt^Scer\UAS.cTa, under the control of Scer\GAL4^GMR.long, in a sev¹⁴ background, have a high proportion of pR8 photoreceptors and a small proportion of yR8 receptors. (Mikeladze-Dvali et al., 2005)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	melt^Scer\UAS.cTa/Scer\GAL4^αTub84B.PL rescues Df(3L)melt^Δ1 (Teleman et al., 2005)
Comments	The growth defects seen in Df(3L)melt^Δ1 homozygous flies are fully rescued by melt^Scer\UAS.cTa with Scer\GAL4^αTub84B.PL or Scer\GAL4^ppl.PP, but not with Scer\GAL4^Ilp3.PC. (Teleman et al., 2005)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	melt^Scer\UAS.cTa
Name Synonym	Saccharomyces cerevisiae UAS construct a of Teleman
Secondary FlyBase IDs

References ( 5 )
Research paper	Terrell et al., 2012, Dev. Dyn. 241(1): 215--228 OTX2 and CRX rescue overlapping and photoreceptor-specific functions in the Drosophila eye. [FBrf0216943] McDonald et al., 2010, Dev. Biol. 347(1): 122--132 Separable transcriptional regulatory domains within Otd control photoreceptor terminal differentiation events. [FBrf0211936] Sprecher et al., 2007, Genes Dev. 21(17): 2182--2195 Adult and larval photoreceptors use different mechanisms to specify the same Rhodopsin fates. [FBrf0205916] Mikeladze-Dvali et al., 2005, Cell 122(5): 775--787 The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors. [FBrf0187233] Teleman et al., 2005, Dev. Cell 9(2): 271--281 Drosophila melted modulates FOXO and TOR activity. [FBrf0187410]

Allele Dmel\meltScer\UAS.cTa

Allele Dmel\melt^Scer\UAS.cTa