FlyBase Allele Report: Dmel\lgs[17E.UAS]

General Information

Symbol

Dmel\lgs^17E.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0193885

Feature type

allele

Associated gene

Dmel\lgs

Associated Insertion(s)

Carried in Construct

P{UAS-lgs.17E}

Also Known As

lgs^17E, UAS-lgs^17E

Key Links

Transgenic product class

missense_variant

(Mosimann et al., 2006)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Mosimann et al., 2006)

Mutagen

in vitro construct

(Mosimann et al., 2006)

Progenitor genotype

Carried in construct

P{UAS-lgs.17E}

Cytology

Description

UAS regulatory sequences drive expression of a mutated form of lgs, which carries the same mutation as the lgs^17E allele.

(Mosimann et al., 2006)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

lgs

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage | somatic clone, with Scer\GAL4^Act5C.PU

(Reim et al., 2014)

visible, with Scer\GAL4^salm.E

(Benchabane et al., 2011)

visible | adult stage, with Scer\GAL4^Dll.PU

(Reim et al., 2014)

visible | adult stage, with Scer\GAL4^nub.PU

(Reim et al., 2014)

visible | adult stage, with Scer\GAL4^pnr.PU

(Reim et al., 2014)

visible | adult stage, with Scer\GAL4^salm.E

(Reim et al., 2014)

visible | adult stage, with Scer\GAL4^vg.PU

(Reim et al., 2014)

visible | adult stage | somatic clone, with Scer\GAL4^Act5C.PU

(Reim et al., 2014)

Phenotype Manifest In

adult thorax, with Scer\GAL4^pnr.PU

(Reim et al., 2014)

embryonic/first instar larval cuticle | embryonic stage, with Scer\GAL4^da.PU

(Reim et al., 2014)

leg, with Scer\GAL4^Dll.PU

(Reim et al., 2014)

sex comb, with Scer\GAL4^Dll.PU

(Reim et al., 2014)

ventral denticle belt | embryonic stage, with Scer\GAL4^da.PU

(Reim et al., 2014)

wing, with Scer\GAL4^salm.E

(Benchabane et al., 2011)

wing margin, with Scer\GAL4^nub.PU

(Reim et al., 2014)

wing margin, with Scer\GAL4^salm.E

(Reim et al., 2014, Mosimann et al., 2006)

wing margin, with Scer\GAL4^vg.PU

(Reim et al., 2014)

wing margin | somatic clone, with Scer\GAL4^Act5C.PU

(Reim et al., 2014)

wing sensillum | somatic clone, with Scer\GAL4^Act5C.PU

(Reim et al., 2014)

wing vein | somatic clone, with Scer\GAL4^Act5C.PU

(Reim et al., 2014)

Detailed Description

Statement

Reference

Expression of lgs^17E.Scer\UAS under the control of Scer\GAL4^salm.E results in wing notches.

(Benchabane et al., 2011)

Expression of lgs^17E.Scer\UAS in the wing pouch primordium, driven by Scer\GAL4^salm.E, causes a notched wing margin phenotype.

(Mosimann et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^salm.E, lgs^17E.UAS has visible | adult stage phenotype, suppressible by Scer\GAL4^salm.E/stg^UAS.cUa

(Reim et al., 2014)

NOT suppressed by

Statement

Reference

Scer\GAL4^salm.E, lgs^17E.UAS has visible | adult stage phenotype, non-suppressible by Diap1^UAS.cUa, Scer\GAL4^salm.E

(Reim et al., 2014)

Scer\GAL4^salm.E, lgs^17E.UAS has visible | adult stage phenotype, non-suppressible by Scer\GAL4^salm.E/Ubi-p5E^HMS01881

(Reim et al., 2014)

Scer\GAL4^salm.E, lgs^17E.UAS has visible | adult stage phenotype, non-suppressible by CSN6^UAS.ORF, Scer\GAL4^salm.E

(Reim et al., 2014)

Enhancer of

Statement

Reference

lgs^17E.UAS/Scer\GAL4^nub.PU is an enhancer of visible | adult stage phenotype of Scer\GAL4^nub.PU, amls^{RNAi.5xUAS.3-ORF}

(Reim et al., 2014)

Suppressor of

Statement

Reference

lgs^17E.UAS, Scer\GAL4^ey.PU, Scer\GAL4^GMR.PU is a suppressor | partially of visible | adult stage phenotype of wg^hs.2sev

(Reim et al., 2014)

lgs^17E.UAS, Scer\GAL4^ey.PU, Scer\GAL4^GMR.PU is a suppressor | partially of decreased size | adult stage phenotype of wg^hs.2sev

(Reim et al., 2014)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^salm.E, lgs^17E.UAS has wing margin phenotype, suppressible by Scer\GAL4^salm.E/stg^UAS.cUa

(Reim et al., 2014)

Scer\GAL4^salm.E, lgs^17E.UAS has wing margin phenotype, suppressible by hyx^UAS.cMa/Scer\GAL4^salm.E

(Mosimann et al., 2006)

Scer\GAL4^salm.E, lgs^17E.UAS has wing margin phenotype, suppressible by Hsap\CDC73^UAS.cMa, Scer\GAL4^salm.E

(Mosimann et al., 2006)

Scer\GAL4^salm.E, lgs^17E.UAS has wing margin phenotype, suppressible by hyx^EP9

(Mosimann et al., 2006)

Scer\GAL4^salm.E, lgs^17E.UAS has wing margin phenotype, suppressible by hyx^EP10

(Mosimann et al., 2006)

NOT suppressed by

Statement

Reference

Scer\GAL4^salm.E, lgs^17E.UAS has wing margin phenotype, non-suppressible by Diap1^UAS.cUa, Scer\GAL4^salm.E

(Reim et al., 2014)

Scer\GAL4^salm.E, lgs^17E.UAS has wing margin phenotype, non-suppressible by Scer\GAL4^salm.E/Ubi-p5E^HMS01881

(Reim et al., 2014)

Scer\GAL4^salm.E, lgs^17E.UAS has wing margin phenotype, non-suppressible by CSN6^UAS.ORF, Scer\GAL4^salm.E

(Reim et al., 2014)

Scer\GAL4^salm.E, lgs^17E.UAS has wing margin phenotype, non-suppressible by hyx¹

(Mosimann et al., 2006)

Scer\GAL4^salm.E, lgs^17E.UAS has wing margin phenotype, non-suppressible by hyx²

(Mosimann et al., 2006)

Enhancer of

Statement

Reference

lgs^17E.UAS/Scer\GAL4^nub.PU is an enhancer of wing margin phenotype of Scer\GAL4^nub.PU, amls^{RNAi.5xUAS.3-ORF}

(Reim et al., 2014)

Suppressor of

Statement

Reference

lgs^17E.UAS, Scer\GAL4^ey.PU, Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of wg^hs.2sev

(Reim et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

The notched wing phenotype of Scer\GAL4^salm.E>lgs^17E.Scer\UAS flies is suppressed by coexpression of either hyx^EP9, hyx^EP10 or hyx^Scer\UAS.cMa. The hyx¹ and hyx² alleles fail to suppress this phenotype.

(Mosimann et al., 2006)

Xenogenetic Interactions

Statement

Reference

Coexpression of the hyx human homologue, Hsap\CDC73^Scer\UAS.cMa, with lgs^17E.Scer\UAS (driven by Scer\GAL4^salm.E) suppresses the notched wing phenotype of lgs^17E.Scer\UAS flies.

(Mosimann et al., 2006)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

lgs^17E.Scer\UAS

lgs^17E.UAS

lgs^17E

(Schertel et al., 2013, Benchabane et al., 2011, Benchabane et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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