A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Allele Dmel\S6kIIScer\UAS.T:Hsap\MYC

General Information
SymbolDmel\S6kIIScer\UAS.T:Hsap\MYCSpeciesD. melanogaster
NameFlyBase IDFBal0194033
Feature typealleleAssociated geneDmel\S6kII
Allele class
Mutagenin vitro construct - regulatory fusion, in vitro construct - coding region fusion
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Description
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FB2013_03
FB2013_02
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hide Nature of the Allele
Allele class
Mutagen
in vitro construct - coding region fusion
(Kim et al., 2006)
in vitro construct - regulatory fusion
(Kim et al., 2006)
Mutations Mapped to the Genome
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion
Statement
Reference
Scer\UAS regulatory sequences drive expression of wild-type S6kII, tagged with T:Hsap\MYC.
(Kim et al., 2006)
Carried in construct
P{UAS-RSK.WT.MYC}
(Kim et al., 2006)
Tagged with
T:Hsap\MYC
(Kim et al., 2006)
Cytology
hide Phenotypic Data
hide Phenotypic Class
visible, with Scer\GAL4GMR.PF
(Kim et al., 2006)
hide Phenotype Manifest In
interommatidial bristle, with Scer\GAL4GMR.PF
(Kim et al., 2006)
ommatidium, with Scer\GAL4GMR.PF
(Kim et al., 2006)
rhabdomere, with Scer\GAL4GMR.PF
(Kim et al., 2006)
wing vein, with Scer\GAL4Bx-MS1096
(Kim et al., 2006)
wing vein, with Scer\GAL4en-e16E
(Kim et al., 2006)
hide Detailed Description
Statement
Reference
Expression of S6kIIScer\UAS.T:Hsap\MYC in the eye, driven by Scer\GAL4GMR.PF, induces a rough eye phenotype with a dramatically reduced number of rhabdomeres. At the pupal level, eyes show a reduction in differentiation of cells into both neuronal and non-neuronal retinal cells. Expression of S6kIIScer\UAS.T:Hsap\MYC under the control of either Scer\GAL4en-e16E or Scer\GAL4Bx-MS1096 induces compartment-specific vein loss in the wing.
(Kim et al., 2006)
hide External Data
Linkouts
hide Interactions
hide Phenotypic Class
hideEnhanced by
Statement
Reference
S6kIIScer\UAS.T:Hsap\MYC, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has visible phenotype, enhanceable by Dsor1[+]/Dsor1LH110
(Kim et al., 2006)
S6kIIScer\UAS.T:Hsap\MYC, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has visible phenotype, enhanceable by phl[+]/phl12
(Kim et al., 2006)
S6kIIScer\UAS.T:Hsap\MYC, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has visible phenotype, enhanceable by Ras85De1B/Ras85D[+]
(Kim et al., 2006)
S6kIIScer\UAS.T:Hsap\MYC, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has visible phenotype, enhanceable by rl+/rl10a
(Kim et al., 2006)
hideSuppressor of
Statement
Reference
S6kIIScer\UAS.T:Hsap\MYC, Scer\GAL4hs.2sev is a suppressor of visible phenotype of Ras85DV12.Scer\UAS, Scer\GAL4hs.2sev
(Kim et al., 2006)
S6kIIScer\UAS.T:Hsap\MYC, Scer\GAL4hs.2sev is a suppressor of visible phenotype of Scer\GAL4hs.2sev, phlScer\UAS.F179
(Kim et al., 2006)
hide Phenotype Manifest In
hideEnhanced by
Statement
Reference
S6kIIScer\UAS.T:Hsap\MYC, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has interommatidial bristle phenotype, enhanceable by Dsor1[+]/Dsor1LH110
(Kim et al., 2006)
S6kIIScer\UAS.T:Hsap\MYC, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has interommatidial bristle phenotype, enhanceable by phl[+]/phl12
(Kim et al., 2006)
S6kIIScer\UAS.T:Hsap\MYC, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has interommatidial bristle phenotype, enhanceable by Ras85De1B/Ras85D[+]
(Kim et al., 2006)
S6kIIScer\UAS.T:Hsap\MYC, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has interommatidial bristle phenotype, enhanceable by rl+/rl10a
(Kim et al., 2006)
S6kIIScer\UAS.T:Hsap\MYC, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has ommatidium phenotype, enhanceable by Dsor1[+]/Dsor1LH110
(Kim et al., 2006)
S6kIIScer\UAS.T:Hsap\MYC, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has ommatidium phenotype, enhanceable by phl[+]/phl12
(Kim et al., 2006)
S6kIIScer\UAS.T:Hsap\MYC, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has ommatidium phenotype, enhanceable by Ras85De1B/Ras85D[+]
(Kim et al., 2006)
S6kIIScer\UAS.T:Hsap\MYC, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has ommatidium phenotype, enhanceable by rl+/rl10a
(Kim et al., 2006)
S6kIIScer\UAS.T:Hsap\MYC, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has rhabdomere phenotype, enhanceable by Dsor1[+]/Dsor1LH110
(Kim et al., 2006)
S6kIIScer\UAS.T:Hsap\MYC, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has rhabdomere phenotype, enhanceable by phl[+]/phl12
(Kim et al., 2006)
S6kIIScer\UAS.T:Hsap\MYC, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has rhabdomere phenotype, enhanceable by Ras85De1B/Ras85D[+]
(Kim et al., 2006)
S6kIIScer\UAS.T:Hsap\MYC, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has rhabdomere phenotype, enhanceable by rl+/rl10a
(Kim et al., 2006)
hideSuppressor of
Statement
Reference
S6kIIScer\UAS.T:Hsap\MYC, Scer\GAL4hs.2sev is a suppressor of interommatidial bristle phenotype of Ras85DV12.Scer\UAS, Scer\GAL4hs.2sev
(Kim et al., 2006)
S6kIIScer\UAS.T:Hsap\MYC, Scer\GAL4hs.2sev is a suppressor of interommatidial bristle phenotype of Scer\GAL4hs.2sev, phlScer\UAS.F179
(Kim et al., 2006)
S6kIIScer\UAS.T:Hsap\MYC, Scer\GAL4hs.2sev is a suppressor of ommatidium phenotype of Ras85DV12.Scer\UAS, Scer\GAL4hs.2sev
(Kim et al., 2006)
S6kIIScer\UAS.T:Hsap\MYC, Scer\GAL4hs.2sev is a suppressor of ommatidium phenotype of Scer\GAL4hs.2sev, phlScer\UAS.F179
(Kim et al., 2006)
S6kIIScer\UAS.T:Hsap\MYC, Scer\GAL4hs.2sev is a suppressor of rhabdomere phenotype of Scer\GAL4hs.2sev, phlScer\UAS.F179
(Kim et al., 2006)
Scer\GAL4hs.2sev/S6kIIScer\UAS.T:Hsap\MYC is a suppressor of eye photoreceptor cell | supernumerary phenotype of sevS11.T:Hsap\MYC
(Kim et al., 2006)
Scer\GAL4hs.2sev/S6kIIScer\UAS.T:Hsap\MYC is a suppressor of rhabdomere phenotype of Ras85DV12.Scer\UAS
(Kim et al., 2006)
hideNOT Suppressor of
Statement
Reference
S6kIIScer\UAS.T:Hsap\MYC, Scer\GAL4hs.2sev is a non-suppressor of eye photoreceptor cell | supernumerary phenotype of Scer\GAL4hs.2sev, rlSem.Scer\UAS.T:Ivir\HA1
(Kim et al., 2006)
hide Additional Comments
hide Genetic Interactions
Statement
Reference
Expression of S6kIIScer\UAS.T:Hsap\MYC, under the control of Scer\GAL4GMR.PF, causes a more severe roughened-eye phenotype and a greater loss of rhabdomeres when expressed in a rl10a/+, Dsor1LH110/+, Ras85De1B/+ or phl12/+ background than when expressed in a wild-type background. The roughened eye and increased rhabdomere phenotypes seen when either phlScer\UAS.F179 or Ras85DV12.Scer\UAS is expressed under the control of Scer\GAL4hs.2sev are suppressed when S6kIIScer\UAS.T:Hsap\MYC is coexpressed. Scer\GAL4hs.2sev>S6kIIScer\UAS.T:Hsap\MYC expression also suppresses the increased photoreceptor cell phenotype seen in sevS11.T:Hsap\MYC flies. Coexpression of S6kIIScer\UAS.T:Hsap\MYC fails to suppress the increased photoreceptor cell phenotype of Scer\GAL4hs.2sev>rlSem.Scer\UAS.T:Ivir\HA1 flies.
(Kim et al., 2006)
hide Xenogenetic Interactions
Statement
Reference
hide Complementation & Rescue Data
Rescues
Scer\GAL4da.G32/S6kIIScer\UAS.T:Hsap\MYC rescues S6kIID1
(Kim et al., 2006)
Comments
hide Stocks ( 0 )
hide Notes on Origin
Discoverer
hide External Crossreferences & Linkouts
Other Crossreferences
Linkouts
hide Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym
RSKWT
(Kim et al., 2006)
S6kIIScer\UAS.T:Hsap\MYC
 
Name Synonym
Secondary FlyBase IDs
hide References ( 1 )
Research paper
Kim et al., 2006, EMBO J. 25(13): 3056--3067
Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development. [FBrf0194603]