|Feature type||allele||Associated gene||Dmel\pyd|
|Allele class||loss of function allele|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Caused by insertion|
|Phenotype Manifest In|
embryonic dorsal branch & cell-cell adherens junction
embryonic ganglionic branch & cell-cell adherens junction
pydBG02748 embryos display defects in tracheal development including dorsal branch fusion problems, ectopic terminal cells, a lack of fusion cells, and ganglionic branch outgrowth defects. The dorsal branch phenotype is not fully penetrant; 2% of embryos show wild-type tracheal systems, 17% show defects in 1 metamere, 43% show defects in 2-4 metameres and 40% show defects in >5 metameres. Fusion defects are occasionally observed in the lateral trunk, although the penetrance of this is lower than for the dorsal branch. pydBG02748/Df(3R)p-XT103 transheterozygotes show the same tracheal phenotypes as pydBG02748 homozygotes. The dorsal branches of pydBG02748 embryos show large loops of intercellular adherens junctions, indicating that cell intercalation is not complete. These intercalation defects are not fully penetrant. Ganglionic branches also show defective cell intercalation.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Partially rescued by|
Expression of either pydScer\UAS.T:Avic\GFP-EGFP or pydScer\UAS.cJa under the control of Scer\GAL4btl.PS partially rescues the tracheal phenotype of pydBG02748 embryos. pydBG02748>pydScer\UAS.T:Avic\GFP-EGFP expression provides full rescue of the tracheal cell intercalation phenotype.
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 1 )|
|Secondary FlyBase IDs|
|References ( 1 )|