Allele Dmel\pyd^BG02748

General Information
Symbol	Dmel\pyd^BG02748	Species	D. melanogaster
Name		FlyBase ID	FBal0194118
Feature type	allele	Associated gene	Dmel\pyd

Allele class	loss of function allele
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	loss of function allele (Jung et al., 2006)
Mutagen	P-element activity (Jung et al., 2006)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Caused by insertion	P{GT1}pyd^BG02748 (Jung et al., 2006)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	dorsal branch primordium (Jung et al., 2006) embryonic dorsal branch & cell-cell adherens junction (Jung et al., 2006) embryonic ganglionic branch & cell-cell adherens junction (Jung et al., 2006) ganglionic branch primordium (Jung et al., 2006) lateral trunk primordium (Jung et al., 2006) presumptive embryonic/larval tracheal system (Jung et al., 2006) presumptive embryonic/larval tracheal system (with Df(3R)p-XT103) (Jung et al., 2006) terminal tracheal cell (Jung et al., 2006) tracheal fusion cell (Jung et al., 2006)
Detailed Description
	Statement Reference pyd^BG02748 embryos display defects in tracheal development including dorsal branch fusion problems, ectopic terminal cells, a lack of fusion cells, and ganglionic branch outgrowth defects. The dorsal branch phenotype is not fully penetrant; 2% of embryos show wild-type tracheal systems, 17% show defects in 1 metamere, 43% show defects in 2-4 metameres and 40% show defects in >5 metameres. Fusion defects are occasionally observed in the lateral trunk, although the penetrance of this is lower than for the dorsal branch. pyd^BG02748/Df(3R)p-XT103 transheterozygotes show the same tracheal phenotypes as pyd^BG02748 homozygotes. The dorsal branches of pyd^BG02748 embryos show large loops of intercellular adherens junctions, indicating that cell intercalation is not complete. These intercalation defects are not fully penetrant. Ganglionic branches also show defective cell intercalation. (Jung et al., 2006)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially rescued by	pyd^BG02748 is partially rescued by pyd^{Scer\UAS.T:Avic\GFP-EGFP}/Scer\GAL4^btl.PS (Jung et al., 2006) pyd^BG02748 is partially rescued by Scer\GAL4^btl.PS/pyd^Scer\UAS.cJa (Jung et al., 2006)
Comments	Expression of either pyd^{Scer\UAS.T:Avic\GFP-EGFP} or pyd^Scer\UAS.cJa under the control of Scer\GAL4^btl.PS partially rescues the tracheal phenotype of pyd^BG02748 embryos. pyd^BG02748>pyd^{Scer\UAS.T:Avic\GFP-EGFP} expression provides full rescue of the tracheal cell intercalation phenotype. (Jung et al., 2006)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	pyd^BG02748
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Jung et al., 2006, Curr. Biol. 16(12): 1224--1231 Polychaetoid/ZO-1 is required for cell specification and rearrangement during Drosophila tracheal morphogenesis. [FBrf0192782]

Allele Dmel\pydBG02748

Allele Dmel\pyd^BG02748