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General Information
Symbol
Dmel\Traf6ex1
Species
D. melanogaster
Name
FlyBase ID
FBal0194141
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Traf2Ex1
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the P{EP} element, resulting in a 2.7kb deletion from within the Traf2 gene.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

No wing notching is seen in Traf6ex1/+ mutant flies. Traf6ex1 homozygous adult wings show mild irregularities and forked tips at the distal end of veins.

Compared with wild-type, homozygous Traf6ex1 mutant flies show elevated viral RNA levels after infection with Rift Valley Fever Virus (RVFV).

Traf6ex1 mutant flies are fully resistant to infection by gram-negative bacteria, and survival rates are comparable to wild-type.

Traf2ex1 adults show no morphological defects.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressor of
Statement
Reference

Traf6ex1 is a suppressor of scutellum phenotype of Scer\GAL4ey.PU, benEP1651

Traf6ex1 is a suppressor of eye phenotype of Scer\GAL4ey.PU, bend09936

Traf6[+]/Traf6ex1 is a suppressor of wing phenotype of N1

Traf6[+]/Traf6ex1 is a suppressor of eye phenotype of Mmus\Gria1Lc.UAS, Scer\GAL4hs.2sev

Traf6[+]/Traf6ex1 is a suppressor | partially of eye phenotype of Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, egrUAS.cIa

NOT Suppressor of
Statement
Reference

Traf6ex1/Traf6ex1 is a non-suppressor of eye phenotype of Scer\GAL4hs.2sev, Tak1UAS.cMa

Additional Comments
Genetic Interactions
Statement
Reference

Traf6ex1 suppresses the rough eye phenotype seen when bend09936 is expressed under the control of Scer\GAL4ey.PU.

Traf6ex1 suppresses the small scutellum phenotype seen when benEP1651 is expressed under the control of Scer\GAL4pnr.PU.

One copy of Traf6ex1 rescues the wing notching phenotype seen in N1 mutant heterozygotes.

One copy of Traf6ex1 rescues the wing notching phenotype seen in Df(1)N-54l9 mutant heterozygotes.

dx1/Traf6ex1 transheterozygotes exhibit a wing vein thickening phenotype.

One copy of Traf6ex1 partially suppresses the wing nicking phenotype seen when krzScer\UAS.T:Ivir\HA1 and dxScer\UAS.T:Zzzz\FLAG are expressed under the control of Scer\GAL4bbg-C96. The resulting flies exhibit loss of L4 vein material.

egrScer\UAS.cIa-induced cell death is partially suppressed in hemizygous Traf6ex1 mutant males.

The small-eye phenotype caused by expression of egrScer\UAS.cIa under the control of Scer\GAL4GMR.PF is strongly suppressed by Traf6ex1/+ and is completely suppressed by Traf6ex1/Traf6ex1.

Homozygosity for Traf6ex1 has no effect on the mutant eye phenotype caused by expression of Tak1Scer\UAS.cMa under the control of Scer\GAL4hs.2sev.

Xenogenetic Interactions
Statement
Reference

A Traf6ex1/+ background rescues the reduced adult eye size phenotype found in Scer\GAL4hs.2sev->Mmus\Gria1Lc.Scer\UAS flies.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (10)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (10)