Allele Scer\GAL4^VGlut-OK371

General Information
Symbol	Scer\GAL4^VGlut-OK371	Species	S. cerevisiae
Name		FlyBase ID	FBal0194519
Feature type	allele	Associated gene	Scer\GAL4

Allele class
Mutagen
Recent Updates
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FB2013_03
FB2013_02	Controlled Vocabulary Terms axon late third instar larval stage increased cell death motor neuron semi-lethal
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Caused by insertion	P{GawB}VGlut^OK371 (Venkiteswaran and Hasan, 2009, Mahr and Aberle, 2006, Meyer and Aberle, 2006, Beuchle et al., 2007, Grosjean et al., 2008, Cheng et al., 2011, Diegelmann et al., 2008, Abou Tayoun et al., 2011, Jepson et al., 2012, Keegan et al., 2011, Shao et al., 2011, Keller et al., 2011, Pulver et al., 2009, Baek and Mann, 2009, Koch et al., 2008, Gao et al., 2008, Johnson et al., 2009, Gao et al., 2008, Kolodziejczyk et al., 2008, Nässel et al., 2008, Boerner and Duch, 2010, Melicharek et al., 2010, Nedelsky et al., 2010, de Haro et al., 2010, Yu et al., 2010, Nicolaï et al., 2010, Cognigni et al., 2011, Slawson et al., 2011, Lanson et al., 2011, Hornstein et al., 2009, Li et al., 2010, Jepson et al., 2011, Beck et al., 2012, Majumdar et al., 2012, Jochum et al., 2012, Jansen et al., 2009, Lloyd et al., 2012, Panz et al., 2012, Xia et al., 2012, Lotti et al., 2012, Li et al., 2010, Dickman et al., 2012)
Cytology
Phenotypic Data
Phenotypic Class
	cell death defective \| third instar larval stage, with Hsap\FUS^{Scer\UAS.T:Hsap\MYC} (Xia et al., 2012) increased cell death \| late third instar larval stage, with Hsap\TARDBP^{Scer\UAS.T:Ivir\haemagglutinin,T:Disc\RFP} (Li et al., 2010) lethal \| pupal stage, with caz^{Scer\UAS.T:Ivir\HA1} (Xia et al., 2012) lethal \| pupal stage, with Hsap\FUS^{R521G.Scer\UAS.T:Hsap\MYC} (Xia et al., 2012) lethal \| pupal stage, with Hsap\FUS^{R521H.Scer\UAS.T:Ivir\HA1} (Lanson et al., 2011) lethal \| pupal stage, with Hsap\FUS^{Scer\UAS.T:Hsap\MYC} (Xia et al., 2012) locomotor behavior defective, with Hsap\FUS^{R518K.Scer\UAS.T:Ivir\HA1} (Lanson et al., 2011) locomotor behavior defective, with Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} (Lanson et al., 2011) locomotor behavior defective, with Hsap\FUS^{R521H.Scer\UAS.T:Ivir\HA1} (Lanson et al., 2011) locomotor behavior defective, with Hsap\TARDBP^{Scer\UAS.T:Ivir\haemagglutinin,T:Disc\RFP} (Li et al., 2010) locomotor behavior defective \| drug conditional, with Hsap\AR^Q65.Scer\UAS (Jochum et al., 2012) locomotor behavior defective \| drug conditional, with Hsap\AR^{S424A.S514A.Scer\UAS} (Jochum et al., 2012) locomotor behavior defective \| late third instar larval stage, with Hsap\TARDBP^{Scer\UAS.T:Ivir\haemagglutinin,T:Disc\RFP} (Li et al., 2010) locomotor behavior defective \| third instar larval stage, with caz^{Scer\UAS.T:Ivir\HA1} (Xia et al., 2012) locomotor behavior defective \| third instar larval stage, with Hsap\FUS^{R521G.Scer\UAS.T:Hsap\MYC} (Xia et al., 2012) locomotor behavior defective \| third instar larval stage, with Hsap\FUS^{Scer\UAS.T:Hsap\MYC} (Xia et al., 2012) locomotor behavior defective \| third instar larval stage, with Hsap\FUS^{Δ32.Scer\UAS.T:Hsap\MYC} (Xia et al., 2012) locomotor behavior defective \| third instar larval stage, with Hsap\FUS^{Δ32.Scer\UAS.T:Uuuu\nls6,T:Hsap\MYC} (Xia et al., 2012) memory defective \| adult stage, with dysb^Scer\UAS.cSa (Shao et al., 2011) neuroanatomy defective \| drug conditional, with Hsap\AR^Q65.Scer\UAS (Jochum et al., 2012) neuroanatomy defective \| drug conditional, with Hsap\AR^{S424A.S514A.Scer\UAS} (Jochum et al., 2012) neuroanatomy defective \| late third instar larval stage, with Hsap\TARDBP^{Scer\UAS.T:Ivir\haemagglutinin,T:Disc\RFP} (Li et al., 2010) neuroanatomy defective \| third instar larval stage, with caz^KK107486 (Xia et al., 2012) neuroanatomy defective \| third instar larval stage, with caz^{Scer\UAS.T:Ivir\HA1} (Xia et al., 2012) neuroanatomy defective \| third instar larval stage, with Hsap\FUS^{R521G.Scer\UAS.T:Hsap\MYC} (Xia et al., 2012) neuroanatomy defective \| third instar larval stage, with Hsap\FUS^{Scer\UAS.T:Hsap\MYC} (Xia et al., 2012) neuroanatomy defective \| third instar larval stage, with Hsap\FUS^{Δ32.Scer\UAS.T:Uuuu\nls6,T:Hsap\MYC} (Xia et al., 2012) neuroanatomy defective \| third instar larval stage, with Pdk1^{Scer\UAS.T:Zzzz\FLAG} (Cheng et al., 2011) partially lethal - majority die, with Hsap\TARDBP^{Scer\UAS.T:Ivir\haemagglutinin,T:Disc\RFP} (Li et al., 2010)
Phenotype Manifest In
	A1-7 ventral longitudinal muscle 3, with caz^{Scer\UAS.T:Ivir\HA1} (Xia et al., 2012) A1-7 ventral longitudinal muscle 3, with Hsap\FUS^{R521G.Scer\UAS.T:Hsap\MYC} (Xia et al., 2012) A1-7 ventral longitudinal muscle 3, with Hsap\FUS^{Scer\UAS.T:Hsap\MYC} (Xia et al., 2012) A1-7 ventral longitudinal muscle 4, with caz^{Scer\UAS.T:Ivir\HA1} (Xia et al., 2012) A1-7 ventral longitudinal muscle 4, with Hsap\FUS^{R521G.Scer\UAS.T:Hsap\MYC} (Xia et al., 2012) A1-7 ventral longitudinal muscle 4, with Hsap\FUS^{Scer\UAS.T:Hsap\MYC} (Xia et al., 2012) abdominal segment motor neuron \| third instar larval stage, with caz^KK107486 (Xia et al., 2012) abdominal segment motor neuron \| third instar larval stage, with caz^{Scer\UAS.T:Ivir\HA1} (Xia et al., 2012) abdominal segment motor neuron \| third instar larval stage, with Hsap\FUS^{R521G.Scer\UAS.T:Hsap\MYC} (Xia et al., 2012) abdominal segment motor neuron \| third instar larval stage, with Hsap\FUS^{Scer\UAS.T:Hsap\MYC} (Xia et al., 2012) abdominal segment motor neuron \| third instar larval stage, with Hsap\FUS^{Δ32.Scer\UAS.T:Uuuu\nls6,T:Hsap\MYC} (Xia et al., 2012) axon \| late third instar larval stage, with Hsap\TARDBP^{Scer\UAS.T:Ivir\haemagglutinin,T:Disc\RFP} (Li et al., 2010) embryonic/larval neuromuscular junction \| third instar larval stage, with caz^{Scer\UAS.T:Ivir\HA1} (Xia et al., 2012) embryonic/larval neuromuscular junction \| third instar larval stage, with Hsap\FUS^{R521G.Scer\UAS.T:Hsap\MYC} (Xia et al., 2012) embryonic/larval neuromuscular junction \| third instar larval stage, with Hsap\FUS^{Scer\UAS.T:Hsap\MYC} (Xia et al., 2012) motor neuron \| late third instar larval stage, with Hsap\TARDBP^{Scer\UAS.T:Ivir\haemagglutinin,T:Disc\RFP} (Li et al., 2010) neuromuscular junction \| drug conditional, with Hsap\AR^Q65.Scer\UAS (Jochum et al., 2012) neuromuscular junction \| drug conditional, with Hsap\AR^{S424A.S514A.Scer\UAS} (Jochum et al., 2012) NMJ bouton, with Gl^{Δ.Scer\UAS.P\T} (Li et al., 2010) NMJ bouton \| late third instar larval stage, with Hsap\TARDBP^{Scer\UAS.T:Ivir\haemagglutinin,T:Disc\RFP} (Li et al., 2010) NMJ bouton \| supernumerary \| third instar larval stage, with Pdk1^{Scer\UAS.T:Zzzz\FLAG} (Cheng et al., 2011) NMJ bouton \| third instar larval stage, with caz^{Scer\UAS.T:Ivir\HA1} (Xia et al., 2012) NMJ bouton \| third instar larval stage, with Hsap\FUS^{R521G.Scer\UAS.T:Hsap\MYC} (Xia et al., 2012) NMJ bouton \| third instar larval stage, with Hsap\FUS^{Scer\UAS.T:Hsap\MYC} (Xia et al., 2012) type I bouton, with Hsap\AR^Q12.Scer\UAS (Nedelsky et al., 2010) type I bouton, with Hsap\AR^Q52.Scer\UAS (Nedelsky et al., 2010) type I bouton, with Hsap\AR^{Q65.G21E.Scer\UAS} (Nedelsky et al., 2010) ventral nerve cord \| third instar larval stage, with caz^KK107486 (Xia et al., 2012) ventral nerve cord \| third instar larval stage, with caz^{Scer\UAS.T:Ivir\HA1} (Xia et al., 2012) ventral nerve cord \| third instar larval stage, with Hsap\FUS^{R521G.Scer\UAS.T:Hsap\MYC} (Xia et al., 2012) ventral nerve cord \| third instar larval stage, with Hsap\FUS^{Scer\UAS.T:Hsap\MYC} (Xia et al., 2012) ventral nerve cord \| third instar larval stage, with Hsap\FUS^{Δ32.Scer\UAS.T:Uuuu\nls6,T:Hsap\MYC} (Xia et al., 2012)
Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference Hsap\TARDBP^{Scer\UAS.T:Ivir\haemagglutinin,T:Disc\RFP}, Scer\GAL4^VGlut-OK371 has locomotor behavior defective \| late third instar larval stage phenotype, suppressible by TBPH^GD6943, Scer\GAL4^VGlut-OK371 (Li et al., 2010, Li et al., 2010)
Suppressor of
Statement Reference Scer\GAL4^VGlut-OK371/S6k^{STDETE.Scer\UAS} is a suppressor \| partially of neuroanatomy defective \| third instar larval stage phenotype of Pdk1³³ (Cheng et al., 2011) Scer\GAL4^VGlut-OK371/snapin^Scer\UAS.cDa is a suppressor \| partially of neurophysiology defective \| recessive phenotype of Df(2L)Exel6277/+, dysb^e01028 (Dickman et al., 2012) TBPH^GD6943, Scer\GAL4^VGlut-OK371 is a suppressor of locomotor behavior defective \| late third instar larval stage phenotype of Hsap\TARDBP^{Scer\UAS.T:Ivir\haemagglutinin,T:Disc\RFP}, Scer\GAL4^VGlut-OK371 (Li et al., 2010, Li et al., 2010)
NOT Suppressor of
Statement Reference Scer\GAL4^VGlut-OK371/Pdk1^{Scer\UAS.T:Zzzz\FLAG} is a non-suppressor of neuroanatomy defective \| third instar larval stage phenotype of Df(3L)CH18/S6k^l-1 (Cheng et al., 2011) Scer\GAL4^VGlut-OK371 is a non-suppressor of neurophysiology defective \| larval stage phenotype of Smn^X7 (Lotti et al., 2012) Scer\GAL4^VGlut-OK371 is a non-suppressor of size defective \| larval stage phenotype of Smn^X7 (Lotti et al., 2012)
Phenotype Manifest In
Suppressor of
Statement Reference Scer\GAL4^VGlut-OK371/S6k^{STDETE.Scer\UAS} is a suppressor \| partially of NMJ bouton \| third instar larval stage phenotype of Pdk1³³ (Cheng et al., 2011)
NOT Suppressor of
Statement Reference Scer\GAL4^VGlut-OK371/Pdk1^{Scer\UAS.T:Zzzz\FLAG} is a non-suppressor of NMJ bouton \| third instar larval stage phenotype of Df(3L)CH18/S6k^l-1 (Cheng et al., 2011) Scer\GAL4^VGlut-OK371/S6k^Scer\UAS.cCa is a non-suppressor of NMJ bouton \| third instar larval stage phenotype of Pdk1³³ (Cheng et al., 2011) Scer\GAL4^VGlut-OK371 is a non-suppressor of embryonic/larval neuromuscular junction \| larval stage phenotype of Smn^X7 (Lotti et al., 2012) Scer\GAL4^VGlut-OK371 is a non-suppressor of embryonic/larval somatic muscle \| larval stage phenotype of Smn^X7 (Lotti et al., 2012)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	dysb^Scer\UAS.cSa/Scer\GAL4^VGlut-OK371 rescues dysb^e01028 (Shao et al., 2011) Gl^Scer\UAS.cLa/Scer\GAL4^VGlut-OK371 rescues Gl^G38S (Lloyd et al., 2012) Scer\GAL4^VGlut-OK371/beag^Scer\UAS.cBa rescues beag¹ (Beck et al., 2012) Scer\GAL4^VGlut-OK371/S6k^Scer\UAS.cCa rescues Df(3L)CH18/S6k^l-1 (Cheng et al., 2011)
Partially rescues	Scer\GAL4^VGlut-OK371/Adar^{3.4.S.Scer\UAS} partially rescues Adar^5G1 (Keegan et al., 2011) Scer\GAL4^VGlut-OK371/BicD^{Scer\UAS.P\T.T:Zzzz\FLAG.T:Zzzz\His6} partially rescues BicD^r5 (Li et al., 2010) Scer\GAL4^VGlut-OK371/Pdk1^{Scer\UAS.T:Zzzz\FLAG} partially rescues Pdk1³³ (Cheng et al., 2011)
Fails to rescue	dysc^Scer\UAS.g/Scer\GAL4^VGlut-OK371 fails to rescue dysc^s168/dysc^c03838 (Jepson et al., 2012) Scer\GAL4^VGlut-OK371/CASK^Scer\UAS.cBa fails to rescue CASK^P18 (Slawson et al., 2011)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Scer\GAL4^OK371 Scer\GAL4^VGlut-OK371
Name Synonym
Secondary FlyBase IDs

References ( 42 )

Generate a list of	All references relating to this allele ( 42 )

List References by type	Research paper ( 41 ) Supplementary material ( 1 )
Recent research papers ( 18 )
	Beck et al., 2012, J. Neurosci. 32(20): 7058--7073 Regulation of Fasciclin II and Synaptic Terminal Development by the Splicing Factor Beag. [FBrf0218385] Dickman et al., 2012, J. Neurosci. 32(25): 8716--8724 Snapin is Critical for Presynaptic Homeostatic Plasticity. [FBrf0218676] Jepson et al., 2012, PLoS Genet. 8(4): e1002671 dyschronic, a Drosophila Homolog of a Deaf-Blindness Gene, Regulates Circadian Output and Slowpoke Channels. [FBrf0218124] Jochum et al., 2012, Biochim. Biophys. Acta 1822(6): 1070--1078 Toxic and non-toxic aggregates from the SBMA and normal forms of androgen receptor have distinct oligomeric structures. [FBrf0218222] Lloyd et al., 2012, Neuron 74(2): 344--360 The p150(Glued) CAP-Gly Domain Regulates Initiation of Retrograde Transport at Synaptic Termini. [FBrf0218160] Lotti et al., 2012, Cell 151(2): 440--454 An SMN-Dependent U12 Splicing Event Essential for Motor Circuit Function. [FBrf0219670] Majumdar et al., 2012, Cell 148(3): 515--529 Critical Role of Amyloid-like Oligomers of Drosophila Orb2 in the Persistence of Memory. [FBrf0217407] Panz et al., 2012, Biol. Cell 104(9): 553--568 A novel role for the non-catalytic intracellular domain of Neprilysins in muscle physiology. [FBrf0219388] Xia et al., 2012, Mol. Neurodegener. 7: 10 Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALS. [FBrf0218020] Abou Tayoun et al., 2011, J. Neurosci. 31(39): 13897--13910 The Drosophila SK Channel (dSK) Contributes to Photoreceptor Performance by Mediating Sensitivity Control at the First Visual Network. [FBrf0216279] Cheng et al., 2011, J. Cell Biol. 194(6): 921--935 S6 kinase localizes to the presynaptic active zone and functions with PDK1 to control synapse development. [FBrf0216911] Cognigni et al., 2011, Cell Metab. 13(1): 92--104 Enteric neurons and systemic signals couple nutritional and reproductive status with intestinal homeostasis. [FBrf0212594] Jepson et al., 2011, J. Biol. Chem. 286(10): 8325--8337 Engineered Alterations in RNA Editing Modulate Complex Behavior in Drosophila: REGULATORY DIVERSITY OF ADENOSINE DEAMINASE ACTING ON RNA (ADAR) TARGETS. [FBrf0213236] Keegan et al., 2011, Nucleic Acids Res. 39(16): 7249--7262 Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects. [FBrf0215032] Keller et al., 2011, Neuron 72(5): 760--775 Glial-derived prodegenerative signaling in the Drosophila neuromuscular system. [FBrf0216904] Lanson et al., 2011, Hum. Mol. Genet. 20(13): 2510--2523 A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43. [FBrf0213887] Shao et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(46): 18831--18836 Schizophrenia susceptibility gene dysbindin regulates glutamatergic and dopaminergic functions via distinctive mechanisms in Drosophila. [FBrf0216775] Slawson et al., 2011, Genetics 187(1): 171--184 Central Regulation of Locomotor Behavior of Drosophila melanogaster Depends on a CASK Isoform Containing CaMK-Like and L27 Domains. [FBrf0212754] Show all research papers ...

Allele Scer\GAL4VGlut-OK371

Allele Scer\GAL4^VGlut-OK371