FlyBase Allele Report: Dmel\wnd[3]

General Information

Symbol

Dmel\wnd³

Species

D. melanogaster

Name

FlyBase ID

FBal0194611

Feature type

allele

Associated gene

Dmel\wnd

Associated Insertion(s)

roo{}wnd³

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

spontaneous

Nature of the Allele

Allele class

loss of function allele

(Collins et al., 2006)

Mutagen

spontaneous

(Collins et al., 2006)

Progenitor genotype

Associated Insertion(s)

roo{}wnd³

Cytology

Description

wnd³ contains a roo\ORF transposon insertion at residue 548.

(Collins et al., 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:19,626,905..19,626,907

(Wolfstetter et al., 2020, Chen et al., 2016, Collins et al., 2006)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates nervous system disease

modeled by unc-104^P350

(Li et al., 2017)

modeled by unc-104¹⁷⁰

(Li et al., 2017)

modeled by unc-104⁵²

(Li et al., 2017)

modeled by unc-104^P350, unc-104^bris

(Li et al., 2017)

modeled by unc-104^GD13526

(Li et al., 2017)

ameliorates fragile X syndrome

modeled by Fmr1^Δ50M

(Russo and DiAntonio, 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage (with Df(3L)ED229)

(Klinedinst et al., 2013)

abnormal wound healing | recessive | third instar larval stage

(Hao et al., 2016)

decreased cell growth rate | recessive | third instar larval stage | conditional

(Hao et al., 2016)

Phenotype Manifest In

axon | third instar larval stage | conditional

(Hao et al., 2016)

motor neuron | third instar larval stage | conditional

(Hao et al., 2016)

NMJ bouton | larval stage (with Df(3L)ED229)

(Klinedinst et al., 2013)

Detailed Description

Statement

Reference

wnd¹/wnd³ transheterozygotes do not show grooming defects, nor any obvious adult mushroom body defects.

(Russo and DiAntonio, 2019)

wnd³/wnd³, but not wnd³/+, leads to a suppressed growth response of motoneuron axons after nerve crush injury in third instar larvae, as compared to wild type.

(Hao et al., 2016)

wnd¹/wnd³ animals show severely reduced axon outgrowth in ddaC neurons after axon severing, while dendrite regeneration after complete removal of the dendrites appears normal.

(Stone et al., 2014)

wnd³/Df(3L)ED229 larvae show an increase in maximum bouton diameter at the neuromuscular junction compared to controls.

(Klinedinst et al., 2013)

Under control conditions, wnd²/wnd³ transheterozygous third instar larvae do not display significant changes in the number of sensory axons per nerve, as compared to controls.

(Bhattacharya et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

wnd³/wnd¹ is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Fmr1^Δ50M/Df(3R)Exel6265

(Russo and DiAntonio, 2019)

wnd³/wnd¹ is a suppressor of abnormal neuroanatomy | adult stage phenotype of Fmr1^Δ50M/Df(3R)Exel6265

(Russo and DiAntonio, 2019)

wnd³/wnd¹ is a suppressor of abnormal size | adult stage phenotype of Fmr1^Δ50M/Df(3R)Exel6265

(Russo and DiAntonio, 2019)

wnd³/wnd¹ is a suppressor of abnormal grooming behavior | progressive phenotype of Fmr1^Δ50M/Df(3R)Exel6265

(Russo and DiAntonio, 2019)

wnd³ is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Fmr1^Δ50M

(Russo and DiAntonio, 2019)

wnd³ is a suppressor of abnormal neurophysiology | third instar larval stage phenotype of Fmr1^Δ50M

(Russo and DiAntonio, 2019)

wnd[+]/wnd³ is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Rheb^UAS.cSa

(Wong et al., 2015)

wnd³/wnd² is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of shot^VV/shot³

(Valakh et al., 2013)

wnd³ is a suppressor of abnormal neurophysiology | third instar larval stage phenotype of Fsn^f06595/Df(2R)Exel7124

(Wu et al., 2007)

Other

Statement

Reference

Trpml¹, wnd[+]/wnd³ has abnormal neuroanatomy | third instar larval stage phenotype

(Wong et al., 2015)

Phenotype Manifest In

Suppressor of

Statement

Reference

wnd³/wnd¹ is a suppressor of adult mushroom body alpha-lobe phenotype of Fmr1^Δ50M/Df(3R)Exel6265

(Russo and DiAntonio, 2019)

wnd³ is a suppressor of NMJ bouton | increased number | third instar larval stage phenotype of Fmr1^Δ50M

(Russo and DiAntonio, 2019)

wnd³ is a suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Fmr1^Δ50M

(Russo and DiAntonio, 2019)

wnd³/wnd¹ is a suppressor of NMJ bouton | increased number | third instar larval stage phenotype of Fmr1^Δ50M/Df(3R)Exel6265

(Russo and DiAntonio, 2019)

wnd[+]/wnd³ is a suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Rheb^UAS.cSa, Scer\GAL4^elav-C155

(Wong et al., 2015)

wnd[+]/wnd³ is a suppressor of NMJ bouton | third instar larval stage phenotype of Rheb^UAS.cSa, Scer\GAL4^elav-C155

(Wong et al., 2015)

wnd³/wnd² is a suppressor of NMJ bouton | increased number | third instar larval stage phenotype of shot^VV/shot³

(Valakh et al., 2013)

wnd³ is a suppressor of synapse phenotype of Rae1^EX28

(Tian et al., 2011)

wnd³ is a suppressor of NMJ bouton phenotype of Rae1^EX28

(Tian et al., 2011)

wnd³ is a suppressor of type I bouton | increased number | third instar larval stage phenotype of Fsn^f06595/Df(2R)Exel7124

(Wu et al., 2007)

wnd³ is a suppressor of embryonic/larval neuromuscular junction phenotype of Fsn^f06595/Df(2R)Exel7124

(Wu et al., 2007)

Other

Statement

Reference

Trpml¹, wnd[+]/wnd³ has neuromuscular junction | third instar larval stage phenotype

(Wong et al., 2015)

Trpml¹, wnd[+]/wnd³ has NMJ bouton | third instar larval stage phenotype

(Wong et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Trpml¹/+;wnd³/+ double heterozygotes show decreased number of NMJ boutons in third instar larvae compared to either Trpml¹/+ or wnd³/+ single heterozygotes.

The increased number of neuromuscular junction boutons in third instar larvae expressing Rheb^Scer\UAS.cSa under the Scer\GAL4^elav-C155 driver is significantly suppressed by combination with wnd³/+.

(Wong et al., 2015)

wnd²/wnd³ fully suppresses the increase in bouton number seen at the neuromuscular junction in shot³/shot^VV third instar larvae.

(Valakh et al., 2013)

A wnd³ background suppresses the bouton number increase and the reduction in bouton size seen in Rae1^EX28 mutants.

(Tian et al., 2011)

The synaptic overgrowth phenotypes seen at the neuromuscular junction in Fsn^f06595/Df(2R)Exel7124 larvae (increased bouton number, increased number of branch points and increased synaptic span) are completely suppressed by wnd³.

(Wu et al., 2007)

wnd³ can fully suppress the hiw^ND8 synaptic overgrowth phenotype.

(Collins et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

wnd³ is rescued by Scer\GAL4^eve.RRa/wnd^UAS.cCa

(Hao et al., 2016)

Not rescued by

wnd³ is not rescued by Scer\GAL4^eve.RRa/wnd^{S301A.S305A.UAS}

(Hao et al., 2016)

Comments

Expression of wnd^Scer\UAS.cCa, but not wnd^{S301A.S305A.Scer\UAS}, under the control of Scer\GAL4^eve.RRa rescues the suppressed growth response of motoneuron axons after nerve crush injury seen in wnd³/wnd³ mutant larvae.

(Hao et al., 2016)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

51999

w^*; wnd³/TM3, Sb¹

Notes on Origin

Discoverer

Arose in: hiw^PF253 stock.

(Collins et al., 2006)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Wnd-3

(Russo and DiAntonio, 2019)

wnd³

(Kim et al., 2024, Wolfstetter et al., 2020, Li et al., 2017, Chen et al., 2016, Hao et al., 2016, Wong et al., 2015, Stone et al., 2014, Kim et al., 2013, Klinedinst et al., 2013, Valakh et al., 2013, Bhattacharya et al., 2012, Nechipurenko and Broihier, 2012, Shin and Diantonio, 2011, Tian et al., 2011, Xiong et al., 2010, Wu et al., 2007, Collins et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (18)

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