FB2025_01 , released February 20, 2025
Allele: Dmel\wndUAS.cCa
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General Information
Symbol
Dmel\wndUAS.cCa
Species
D. melanogaster
Name
FlyBase ID
FBal0194612
Feature type
allele
Associated gene
Dmel\wnd
Associated Insertion(s)
Carried in Construct
P{UAS-wnd.C}
Also Known As
UAS-wnd
Key Links
Transgenic product class
wild_type
(Collins et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Collins et al., 2006)
Mutagen
in vitro construct
(Collins et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-wnd.C}
Cytology
Description

UASt regulatory sequences drive expression of wnd coding sequences.

(Collins et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
wnd
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  cancer
      modeled by AlkUAS.cLa
      (Wolfstetter et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of wndScer\UAS.cCa in C4 da neurons, under the control of Scer\GAL4ppk.PG, results in dramatic overgrowth of the presynaptic arbors.

      (Kim et al., 2013)

      Expression of wndScer\UAS.cCa under the control of Scer\GAL4BG380 has no effect on maximum bouton diameter at the larval neuromuscular junction.

      (Klinedinst et al., 2013)

      Expression of wndScer\UAS.cCa under the control of either Scer\GAL4NP4132 or Scer\GAL4NP7175 (limited to 4 days using Scer\GAL80ts.αTub84B) results in enhanced long term memory formation compared with controls. Learning is unaffected. The morphology of the mushroom body is unaffected.

      (Huang et al., 2012)

      Expression of wndScer\UAS.cCa under the control of Scer\GAL4unspecified in a hiwunspecified background causes embryonic lethality.

      Expression of wndScer\UAS.cCa under the control of Scer\GAL4VGlut results in synaptic overgrowth: bouton number and branching are increased by over 4-fold, synaptic area is increased 2.5-fold, bouton size and the average intensity of synaptic vesicle markers are reduced 4-fold.

      Expression of wndScer\UAS.cCa under the control of Scer\GAL4unspecified in postsynaptic muscles results in no observable defects.

      (Collins et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      wndUAS.cCa has abnormal neuroanatomy phenotype, suppressible by Dscam118

      (Kim et al., 2013)
      Suppressor of
      Statement
      Reference

      Scer\GAL4BG380/wndUAS.cCa is a suppressor of abnormal neuroanatomy | larval stage phenotype of Aplip1ex

      (Klinedinst et al., 2013)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The dramatic overgrowth of presynaptic arbors found in C4 da neurons expressing wndScer\UAS.cCa (under the control of Scer\GAL4ppk.PG) is completely abolished in a Dscam118 MARCM clone background.

      (Kim et al., 2013)

      Expression of wndScer\UAS.cCa under the control of Scer\GAL4BG380 suppresses the increase in maximum bouton diameter which is seen at the neuromuscular junction in Aplip1ex larvae.

      (Klinedinst et al., 2013)

      Expression of bskK53R.Scer\UAS (under the control of Scer\GAL4BG380) suppresses the wndScer\UAS.cCa synaptic phenotype, reducing the number of synaptic boutons and branches and increasing bouton size and the intensity of synaptic vesicle markers.

      Co-expression of kayFbz.Scer\UAS, under the control of Scer\GAL4BG380, with wndScer\UAS.cCa in neurons suppresses the wnd gain-of-function phenotype, leading to a 38% reduction in synaptic bouton number, a 52% reduction in synaptic branching, a 54% increase in bouton size, and a 3.8-fold increase in the intensity of staining of synaptic vesicle markers.

      (Collins et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4eve.RRa/wndUAS.cCa rescues wnd3

      (Hao et al., 2016)
      Comments

      Expression of wndScer\UAS.cCa under the control of Scer\GAL4eve.RRa rescues the suppressed growth response of motoneuron axons after nerve crush injury seen in wnd3/wnd3 mutant larvae.

      (Hao et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      wndScer\UAS.cCa
      wndUAS.cCa
      Name Synonyms
      Secondary FlyBase IDs
        References (12)