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General Information
Symbol
Dmel\rdx5
Species
D. melanogaster
Name
FlyBase ID
FBal0194657
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G13982347T

Reported nucleotide change:

G?T

Amino acid change:

Q193H | rdx-PE

Reported amino acid change:

Q193H

Comment:

Mutation reported in exon 5, which is only found in rdx-RE.

Nucleotide change:

A13969983T

Reported nucleotide change:

A?T

Amino acid change:

D227V | rdx-PA; D195V | rdx-PB; D224V | rdx-PC; D650V | rdx-PE; D227V | rdx-PF

Reported amino acid change:

D653V

Comment:

Approximate location of rdx5-2 mutation. It was reported as a D653V mutation but there is no D residue at position 653 in the reference sequence. The closest D residues are at 650 and 656. The site of the mutation was reported with respect to rdx-PE.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

rdx5 encodes for two missense mutations, in exon 5 and exon 10 respectively.

Amino acid replacement: Q193H.

Nucleotide substitution: G?T.

Amino acid replacement: D653V.

Nucleotide substitution: A?T.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

A few rdx5 homozygote embryos hatch, but none survive beyond first instar.

Germline clones (lacking both maternal and zygotic rdx) of rdx5 do not generate eggs.

rdx5 homozygous clones are the same size as their wild-type counterparts in eye and wing imaginal discs.

Wings filled with unmarked rdx5 clones (28 of 40 wings) exhibit a mild elongation of the anterior compartment.

rdx5 pupal ommatidia, at 36-42 hours of pupation, exhibit misaligned primary cells (40% of ommatidia) that sometimes fail to enclose cone cells (6%), as well as reduced numbers of cone cells (4%), inappropriate numbers of lattice cells (56%), ommatidial fusions (2%), and misplaced bristles (19%).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement
Reference

rdx5 is a suppressor of sex comb phenotype of Pc1

rdx5 is a suppressor of metathoracic leg phenotype of Pc1

rdx5 is a suppressor of mesothoracic leg phenotype of Pc1

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Based on embryonic and larval lethality, the following rdx alleles can be ranked from strongest to weakest as follows: rdx5 > rdx6 > rdx4 = rdx1.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (3)