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General Information
Symbol
Dmel\rdx6
Species
D. melanogaster
Name
FlyBase ID
FBal0194658
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

rdx6 encodes a splice junction mutation (an A to G change in the 23rd nucleotide of the intron between exons 12 and 13).

Nucleotide substitution: A?G.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous rdx6 embryos fail to hatch.

Embryos derived from rdx6 germline clones (lacking both maternal and zygotic rdx) display a spectrum of developmental defects, ranging from normal patterning (2%), through to a complete failure of cellularization (75%). An intermediate class (23%) includes errors in segmental patterning. It also includes embryos that develop at one end, but that slump at the other end into an amorphous mass, a phenotype most accurately described as roadkill. The failure of cellularization in most rdx6 germline clone embryos reflects severe defects during the early mitotic cycles. Abnormalities include mitotic asynchrony, uneven nuclear spacing, failed anaphase resolution and multipolar mitotic figures.

rdx6 homozygous clones are the same size as their wild-type counterparts in eye and wing imaginal discs.

In embryonic rdx6 germline clones mitoses are asynchronous, nuclear spacing is uneven, mitotic figures are highly abnormal, and much of the DNA sinks into the interior of the embryo.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement
Reference

rdx6 is a suppressor of sex comb phenotype of Pc1

rdx6 is a suppressor of metathoracic leg phenotype of Pc1

rdx6 is a suppressor of mesothoracic leg phenotype of Pc1

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Based on embryonic and larval lethality, the following rdx alleles can be ranked from strongest to weakest as follows: rdx5 > rdx6 > rdx4 = rdx1.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (3)