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General Information
Symbol
Dmel\upd2Δ3-62
Species
D. melanogaster
Name
FlyBase ID
FBal0194746
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
upd2Δ
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

A 2530 bp deletion resulting from the imprecise excision of P{Mae-UAS.6.11}upd2GG01031, which extends from 2264bp upstream of the upd2 AUG codon to 266bp downstream.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the P{Mae-UAS.6.11} element, which results in deletion of 2530bp of the upd2 genomic region, from 2264bp upstream of the AUG codon to 266bp downstream. This removes the 5'UTR and coding sequence for the first 89 amino acid residues of the protein product.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Hemizygous adult males appear smaller and slimmer than wild-type controls. Wing area is reduced by 10% overall and there is a significant reduction in both cell number and cell size compared to wild type.

Mutant adults show a significant reduction in triacylglycerol levels and a significant increase in circulating glucose levels compared to controls.

Mutant adults do not show defects in feeding behaviour.

Mutant larvae show a striking accumulation of lipid droplets in oenocytes under fed conditions, in contrast to wild-type controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
NOT suppressed by
Suppressor of
NOT Suppressor of
Phenotype Manifest In
Suppressed by
NOT suppressed by
Statement
Reference
Suppressor of
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

Expression of upd1dsRNA.Scer\UAS.cUa partially suppresses the overgrowth and invasion of the nerve cord seen in l(2)glunspecified mutant eye-antennal disc clones that simultaneously express Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU. The phenotype is further suppressed when the clones are generated in a upd2Δ3-62 mutant background.

upd2Δ3-62 does not suppress the overgrowth and invasion of the nerve cord seen in l(2)glunspecified mutant eye-antennal disc clones that simultaneously express Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU.

Xenogenetic Interactions
Statement
Reference

Expression of Bhal\NaChBacScer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4Ilp3.PB rescues the reduced wing area of upd2Δ3-62 mutants.

Expression of ShEKO.Scer\UAS.T:Avic\GFP-GL under the control of Scer\GAL4Ilp3.PB does exacerbate the reduced wing area phenotype of upd2Δ3-62 mutants.

Expression of Hsap\LEPScer\UAS.cRa under the control of Scer\GAL4Cg.PA rescues the reduced wing area and reduced triacylglycerol levels seen in upd2Δ3-62 flies.

Complementation and Rescue Data
Comments

The reduction in wing size and reduction in triacylglycerol levels seen in upd2Δ3-62 flies is rescued by expression of upd2Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4Cg.PA.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (8)