FB2025_01 , released February 20, 2025
Allele: Dmel\tkvRNAi.UAS
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General Information
Symbol
Dmel\tkvRNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0194773
Feature type
allele
Associated gene
Dmel\tkv
Associated Insertion(s)
Carried in Construct
P{UAS-tkv.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Crickmore and Mann, 2006)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Crickmore and Mann, 2006)
Mutagen
in vitro construct
(Crickmore and Mann, 2006, Crickmore and Mann, 2006)
Progenitor genotype
Carried in construct
P{UAS-tkv.RNAi}
Cytology
Description

An inverted repeat corresponding to the final exon of tkv, separated by the second intron from w, is under the control of UAS sequences.

(Crickmore and Mann, 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
tkv
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of tkvdsRNA.Scer\UAS (causing RNAi of the tkv gene) in the wings and halteres, under the control of both Scer\GAL4vg.int2.1 and Scer\GAL4tub, leads to a reduction of haltere size by 30 to 60% in proportion to wild-type halteres.

      (Crickmore and Mann, 2006)

      Expression of tkvdsRNA.Scer\UAS (leading to RNAi of the tkv gene) in the wing and haltere, driven by Scer\GAL4tub and Scer\GAL4vg.int2.1, leads to an increase in haltere size and a decrease in wing size.

      (Crickmore and Mann, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Transfected into flies to study the effect of dsRNA interference (RNAi) of the tkv gene on dpp signalling and appendage size.

      (Crickmore and Mann, 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      tkvRNAi.UAS
      tkvdsRNA.Scer\UAS
      tkvdsRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)