Allele Dmel\klg^GS10439

General Information
Symbol	Dmel\klg^GS10439	Species	D. melanogaster
Name		FlyBase ID	FBal0195065
Feature type	allele	Associated gene	Dmel\klg

Map ( GBrowse )	Untitled Document
Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 3R:18,724,949..18,724,949 (Gregory et al., 2007, Matsuno et al., 2009)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference The klg[GS10439] mutation results from an insertion of a P-UAS transposon 75 bp upstream of the proposed transcription start site. (Matsuno et al., 2009) Insertion oriented to drive expression in the sense direction starting upstream of the coding region. (Gregory et al., 2007)
Caused by insertion	P{GSV6}klg^GS10439 (Gregory et al., 2007, Matsuno et al., 2009)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| larval stage \| recessive (Matsuno et al., 2009) memory defective (with klg^E226) (Matsuno et al., 2009) viable (with klg^E226) (Matsuno et al., 2009)
Phenotype Manifest In

Detailed Description
	Statement Reference 1-day memory after spaced training is disrupted in heterozygous klg[GS10439]/klg[E226] flies. The klg[GS10439] mutation is recessive for impaired memory. (Matsuno et al., 2009)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference klg^E226/klg^GS10439 is a suppressor of memory defective \| heat sensitive phenotype of N^Hsp70Bb.PL (Matsuno et al., 2009) klg^GS10439, Scer\GAL4^GMR.PF, Scer\GAL4^GMR.PF is a suppressor \| partially of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, pbl^{ΔDH497-549.Scer\UAS} (Gregory et al., 2007)
Phenotype Manifest In
Suppressor of
Statement Reference klg^GS10439, Scer\GAL4^GMR.PF, Scer\GAL4^GMR.PF is a suppressor \| partially of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, pbl^{ΔDH497-549.Scer\UAS} (Gregory et al., 2007)
Additional Comments
Genetic Interactions
Statement Reference The enhancement of long-term memory by N[Hsp70Bb.PL] over-expression is suppressed in klg[GS10439]/klg[E226] flies. (Matsuno et al., 2009)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	klg^ruslan/klg^GS10439 is rescued by Scer\GAL4^klg-ruslan, klg^GS10439 (Matsuno et al., 2009, Matsuno et al., 2009)
Partially rescued by	klg^E226/klg^GS10439 is partially rescued by Scer\GAL4^hs.PB, klg^GS10439 (Matsuno et al., 2009, Matsuno et al., 2009)
Rescues	Scer\GAL4^klg-ruslan, klg^GS10439 rescues klg^ruslan/klg^GS10439 (Matsuno et al., 2009, Matsuno et al., 2009)
Partially rescues	Scer\GAL4^hs.PB, klg^GS10439 partially rescues klg^E226/klg^GS10439 (Matsuno et al., 2009, Matsuno et al., 2009)
Comments	The Scer\GAL4[klg-ruslan] driver in klg[ruslan] induces Scer\UAS dependent klg expression in klg[GS10439] leading to the rescue of the long-term memory defects in klg[ruslan]/klg[GS10439] flies. 1-day memory after spaced training improved significantly in heat-shocked Scer\GAL4[hs.PB]/+; klg[GS10439]/klg[E226] flies. (Matsuno et al., 2009)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	klg^GS10439 (Matsuno et al., 2009)
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Matsuno et al., 2009, Proc. Natl. Acad. Sci. U.S.A. 106(1): 310--315 The Drosophila cell adhesion molecule Klingon is required for long-term memory formation and is regulated by Notch. [FBrf0206600] Gregory et al., 2007, Fly 1(1): 13--22 A Drosophila overexpression screen for modifiers of Rho signalling in cytokinesis. [FBrf0199094]

Allele Dmel\klgGS10439

Allele Dmel\klg^GS10439