Mutant adults show a significant decrease in the number of dorsomedial cluster, dorsolateral cluster 1 and posteriomedial cluster dopaminergic neurons in the brain under oxidative stress conditions compared to wild-type flies.
Mutant flies show reduced survival compared to controls when fed with hydrogen peroxide.
Oxidative stress conditions result in a large increase in apoptosis in the brains of mutant larvae compared to the level seen in wild-type controls.
Mutants show reduced survival after UV irradiation compared to wild type.
Five day old flies show reduced climbing ability compared to wild type.
mutants do not display any external phenotypic defects.
The morphology of dopaminergic neurons in dj-1βex54
mutant brains show no obvious abnormalities, and the neuronal axons seem normally projected as compared to age-matched wild type controls, even at 30 days of age.
The number of dopaminergic neurons in dj-1βex54
mutant brains is normal and there is no evidence of Lewy body formation.
The climbing ability of dj-1βex54
mutants is reduced to about half of that of wild type even on the first day of eclosion, and almost completely lost after 30 days, indicating that dj-1βex54
mutants show a premature loss of climbing ability. The declining rate over time in dj-1βex54
mutants and wild type are similar though.