Mutant adults show a significant decrease in the number of dorsomedial cluster, dorsolateral cluster 1 and posteriomedial cluster dopaminergic neurons in the brain under oxidative stress conditions compared to wild-type flies.
Mutant flies show reduced survival compared to controls when fed with hydrogen peroxide.
Oxidative stress conditions result in a large increase in apoptosis in the brains of mutant larvae compared to the level seen in wild-type controls.
Mutants show reduced survival after UV irradiation compared to wild type.
Five day old flies show reduced climbing ability compared to wild type.
dj-1βex54 mutants do not display any external phenotypic defects.
The morphology of dopaminergic neurons in dj-1βex54 mutant brains show no obvious abnormalities, and the neuronal axons seem normally projected as compared to age-matched wild type controls, even at 30 days of age.
The number of dopaminergic neurons in dj-1βex54 mutant brains is normal and there is no evidence of Lewy body formation.
The climbing ability of dj-1βex54 mutants is reduced to about half of that of wild type even on the first day of eclosion, and almost completely lost after 30 days, indicating that dj-1βex54 mutants show a premature loss of climbing ability. The declining rate over time in dj-1βex54 mutants and wild type are similar though.