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General Information
Symbol
Dmel\dj-1βex54
Species
D. melanogaster
Name
FlyBase ID
FBal0195124
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Imprecise excision of the dj-1βGE23381 P-element resulted in an approximately 450 bp deletion, removing the first two exons and part of the third exon including the translation start site.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
is ameliorated by Daxx1
Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
 
dj-1βex54 mutants model Parkinson's disease under oxidative stress conditions.
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Mutant adults show a significant decrease in the number of dorsomedial cluster, dorsolateral cluster 1 and posteriomedial cluster dopaminergic neurons in the brain under oxidative stress conditions compared to wild-type flies. Mutant flies show reduced survival compared to controls when fed with hydrogen peroxide. Oxidative stress conditions result in a large increase in apoptosis in the brains of mutant larvae compared to the level seen in wild-type controls. Mutants show reduced survival after UV irradiation compared to wild type. Five day old flies show reduced climbing ability compared to wild type.
dj-1βex54 mutants do not display any external phenotypic defects. The morphology of dopaminergic neurons in dj-1βex54 mutant brains show no obvious abnormalities, and the neuronal axons seem normally projected as compared to age-matched wild type controls, even at 30 days of age. The number of dopaminergic neurons in dj-1βex54 mutant brains is normal and there is no evidence of Lewy body formation. The climbing ability of dj-1βex54 mutants is reduced to about half of that of wild type even on the first day of eclosion, and almost completely lost after 30 days, indicating that dj-1βex54 mutants show a premature loss of climbing ability. The declining rate over time in dj-1βex54 mutants and wild type are similar though.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
The reduced survival and reduction in number of dopaminergic neurons in the brain seen in dj-1βex54 adults under oxidative stress conditions are suppressed if the animals are also mutant for DLP1. The reduced survival seen in dj-1βex54 adults under oxidative stress conditions are suppressed if the animals are also mutant for DLP2. The increased apoptosis seen in the brains of dj-1βex54 larvae under oxidative stress conditions is suppressed if the animals are also mutant for DLP1. The sensitivity to UV irradiation seen in dj-1βex54 animals is suppressed if they are also mutant for either DLP1 or DLP2. The reduced climbing ability of dj-1βex54 flies is suppressed by DLP1.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (4)