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General Information
Symbol
Dmel\Sec6175
Species
D. melanogaster
Name
FlyBase ID
FBal0195147
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

sec6175 is the product of an imprecise excision of P{EP}EP2021 that deletes 1720 bp of DNA upstream of the original P{EP}EP2021 insertion site, thus removing the DNA encoding the 455 carboxy-terminal amino acids of the sec6 protein.

Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

sec6175 mutant animals fail to grow as larvae and die at approximately 72 hours after egg laying.

sec6175 hemizygous and homozygous animals show identical phenotypes.

Follicles containing a sec6175 germ-line clone show no apparent defects during early stages. However, by stage 6-7, plasma membrane is undetectable between germ-line cells, ring canals collapse to a single clump within the germline cyst, and nuclei show an irregular arrangement. sec6175 mutant follicles are not observed past stage 7, suggesting that they degenerate.

Eye development is abolished when sec6175 mutant clones are induced in the eye and wild type sister clones are ablated.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Isolated as an imprecise excision of P{EP}EP2021.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Sec6175
sec6Δ175
Name Synonyms
Secondary FlyBase IDs
    References (2)