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General Information
Symbol
Dmel\Drp1+t9.4
Species
D. melanogaster
Name
FlyBase ID
FBal0195692
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

9.35kb genomic fragment containing Drp1 sequences, obtained from BAC30P05.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
 

Drp1+t9.4 ameliorates the bioenergetic defects seen in the Pink1B9 Parkinson's model.

Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

One copy of Drp1+t9.4 increases mitochondrial fission.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference

Drp1+t9.4 is a non-suppressor of male sterile phenotype of Pink1B9

Phenotype Manifest In
Suppressor of
Statement
Reference

Drp1+t9.4 is a suppressor | partially of adult thorax phenotype of Pink1B9

Drp1+t9.4 is a suppressor | partially of mitochondrion phenotype of Pink1B9

NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of Drp1+t9.4 does not rescue the defects in mitochondrial morphology seen in dopaminergic neurons expressing either AconS677A.Scer\UAS or AconScer\UAS.cEa under the control of Scer\GAL4ple.PF.

Pink1B9 ; Acon1/+ ; Drp1+t9.4/+ animals show increased flight ability compared to either Pink1B9 ; Acon1/+ or Pink1B9 ; Drp1+t9.4/+ animals.

Pink1B9 ; AconMB09176/+ ; Drp1+t9.4/+ animals show increased flight ability compared to either Pink1B9 ; AconMB09176/+ or Pink1B9 ; Drp1+t9.4/+ animals.

Drp1+t9.4 opa1-likeunspecified/+ Df(3L)Pmi-PGRP-LD flies show no rescue of the Df(3L)Pmi-PGRP-LD abnormal mitochondrial morphology phenotype.

Expression of Drp1+t9.4 results in partial rescue of the thoracic indentation, impaired flight, impaired climbing, and mitochondrial morphological phenotypes of Pink1B9 hemizygous mutants.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Drp1+t9.4
Name Synonyms
Secondary FlyBase IDs
    References (8)