Allele Dmel\Dscam^unspecified

General Information
Symbol	Dmel\Dscam^unspecified	Species	D. melanogaster
Name		FlyBase ID	FBal0195706
Feature type	allele	Associated gene	Dmel\Dscam

Allele class
Mutagen
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective (Hattori et al., 2007)
Phenotype Manifest In
	antennal lobe (Hattori et al., 2007) antennal lobe glomerulus (Hattori et al., 2007) mushroom body (Hattori et al., 2007) olfactory receptor neuron (Hattori et al., 2007)
Detailed Description
	Statement Reference Dscam null mutant homozygotes show loss of glomerular boundaries in the antennal lobe, such that axons of a given olfactory receptor neuron class target more than one glomerulus in each antennal lobe. Discrete glomeruli are still formed, but their stereotyped arrangement within the antennal lobe is highly disrupted. Sister branches of single Dscam^unspecified mushroom body neurons in an otherwise wild-type background show a high frequency of segregation defects, often failing to segregate into the two mushroom body lobes. (Hattori et al., 2007) Homozygous mutant v'ada neuron clones do not have a significantly different territory size from that of control clones. (Matthews et al., 2007)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	Dscam^unspecified is rescued by Dscam^+t73.3 (Venken et al., 2006)
Partially rescued by	Dscam^unspecified is partially rescued by Scer\GAL4^elav-C155/Dscam^{1.30.30.2.Scer\UAS.cZa} (Zhan et al., 2004) Dscam^unspecified is partially rescued by Scer\GAL4^elav-C155/Dscam^{11.31.25.2.Scer\UAS} (Zhan et al., 2004)
Not rescued by	Dscam^unspecified is not rescued by Scer\GAL4^elav-C155/Dscam^{1.30.30.1.Scer\UAS} (Zhan et al., 2004) Dscam^unspecified is not rescued by Scer\GAL4^elav-C155/Dscam^{7.27.25.1.Scer\UAS.cZa} (Zhan et al., 2004) Dscam^unspecified is not rescued by Scer\GAL4^elav-C155/Dscam^{11.31.25.1.Scer\UAS} (Zhan et al., 2004) Dscam^unspecified is not rescued by Scer\GAL4^elav-C155/Dscam^{12.20.19.1.Scer\UAS} (Zhan et al., 2004)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Dscam^unspecified
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Hattori et al., 2007, Nature 449(7159): 223--227 Dscam diversity is essential for neuronal wiring and self-recognition. [FBrf0205027] Matthews et al., 2007, Cell 129(3): 593--604 Dendrite self-avoidance is controlled by Dscam. [FBrf0200892] Venken et al., 2006, Science 314(5806): 1747--1751 P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster. [FBrf0194996] Zhan et al., 2004, Neuron 43(5): 673--686 Analysis of Dscam diversity in regulating axon guidance in Drosophila mushroom bodies. [FBrf0180574]

Allele Dmel\Dscamunspecified

Allele Dmel\Dscam^unspecified