Allele Dmel\X11L^Scer\UAS.cMa

General Information
Symbol	Dmel\X11L^Scer\UAS.cMa	Species	D. melanogaster
Name	Saccharomyces cerevisiae UAS construct a of Matsuno	FlyBase ID	FBal0195804
Feature type	allele	Associated gene	Dmel\X11L

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Vishnu et al., 2006, Hase et al., 2002)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of X11L. (Vishnu et al., 2006) Scer\UAS regulatory sequences drive expression of a full-length X11L cDNA. (Hase et al., 2002)
Carried in construct	P{UAS-X11L.M} (Vishnu et al., 2006, Hase et al., 2002)
Cytology
Phenotypic Data
Phenotypic Class
	increased cell death, with Scer\GAL4^GMR.PY (Hase et al., 2002) visible, with Scer\GAL4^GMR.PY (Hase et al., 2002)
Phenotype Manifest In
	eye, with Scer\GAL4^GMR.PY (Hase et al., 2002) eye disc, with Scer\GAL4^GMR.PY (Hase et al., 2002) four cone-cell ommatidial precursor cluster, with Scer\GAL4^MZ1369 (Vishnu et al., 2006) interommatidial bristle, with Scer\GAL4^MZ1369 (Vishnu et al., 2006) ommatidial precursor cluster, with Scer\GAL4^MZ1369 (Vishnu et al., 2006) ommatidium, with Scer\GAL4^MZ1369 (Vishnu et al., 2006) primary pigment cell, with Scer\GAL4^MZ1369 (Vishnu et al., 2006) rhabdomere \| ectopic, with Scer\GAL4^MZ1369 (Vishnu et al., 2006)
Detailed Description
	Statement Reference Expression of X11L^Scer\UAS.cMa in the developing optic lobe and eye disc, driven by Scer\GAL4^MZ1369, results in the formation of rough eyes. Rhabdomeres in these flies are not restricted to the distal side of the fenestrated membrane, as in wild-type flies, but are found beneath this structure, displacing the lamina. Pupal eyes that express X11L^Scer\UAS.cMa under the control of Scer\GAL4^MZ1369 frequently display fused ommatidia, misplaced bristle complexes and reduced numbers of cone cells from four to two or even to a single cell. One or both of the primary pigment cells are sometimes missing after apparently having failed to differentiate properly. (Vishnu et al., 2006) Expression of X11L[Scer\UAS.cMa] under the control of Scer\GAL4[GMR.PY] results in defects in eye morphology. Eye discs of these animals show an increase in cell death compared to wild type. (Hase et al., 2002)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer	K. Matsuno

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	X11L^Scer\UAS.cMa
Name Synonym	Saccharomyces cerevisiae UAS construct a of Matsuno
Secondary FlyBase IDs

References ( 2 )
Research paper	Vishnu et al., 2006, Dev. Biol. 289(2): 296--307 The adaptor protein X11Lalpha/Dmint1 interacts with the PDZ-binding domain of the cell recognition protein Rst in Drosophila. [FBrf0190176] Hase et al., 2002, J. Neurochem. 81(6): 1223--1232 Expression and characterization of the Drosophila X11-like/Mint protein during neural development. [FBrf0149072]

Allele Dmel\X11LScer\UAS.cMa

Allele Dmel\X11L^Scer\UAS.cMa