Open Close
General Information
Symbol
Dmel\jetc
Species
D. melanogaster
Name
common
FlyBase ID
FBal0195806
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:
T4949049A
Reported nucleotide change:
T?A
Amino acid change:
F209I | jet-PA; F209I | jet-PB
Reported amino acid change:
F209I
Comment:
Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Nucleotide substitution: T?A.
Amino acid replacement: F?I.
Amino acid replacement: F209I.
The F209I substitution is within a conserved 'LRR' domain.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
jetc mutants can be trained to light:dark LD cycles, but take longer to be re-entrained to a new schedule than wild-type flies. The behaviour of these mutant flies within LD and constant darkness is not different to wild-type flies. While few wild-type flies show rhythmic behaviour in constant light conditions, jetc, jetc/jetr, jetc/Df(2L)Exel8012 and jetc/Df(2L)Exel7021 mutants all show rhythmic behaviour under these conditions. Additionally, jetr mutants show reduced responses to light pulses compared to wild-type flies.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
jetc/jet[+], timls has locomotor rhythm defective phenotype, enhanceable by cry[+]/cryb
jetc, timls/tim[+] has locomotor rhythm defective phenotype, enhanceable by cry[+]/cryb
Other
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
timls, jetc double mutants are referred to as "Veela" flies. 85% of timls/timls, jetc/jetc (Veela/Veela) double mutants show anomalous rhythmicity when kept in constant light, while 31% of timls/+, jetc/+ (Veela/+) double heterozygotes show this phenotype. Flies of this genotype behave normally when kept in constant darkness. timls/+, jetc/+ (Veela/+); cryb/+ flies exhibit robust rhythmicity in constant light, this phenotype is stronger than in timls/+, jetc/+ (Veela/+) flies and is not seen in cryb/+ flies. tims, jetc show behavioral arrhythmicity in constant light conditions, like wild-type flies. timls/tim01, jetc (Veela/tim01) flies show 22% anomalous rhythmicity when kept in constant light, while flies of the same genotype that additionally carry one copy of the timper3'UTR.tim.T:Ivir\HA1 transgene (which has the same coding sequence as the timls allele) show 63% rhythmicity in constant light.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments
Expression of the jetScer\UAS.cKa transgene, under the control of either Scer\GAL4cry.PU or Scer\GAL4tim.PE, partially rescues the reduced light response phenotype of jetc mutants.
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)