Allele Dmel\jet^r

General Information
Symbol	Dmel\jet^r	Species	D. melanogaster
Name	rare	FlyBase ID	FBal0195807
Feature type	allele	Associated gene	Dmel\jet

Allele class
Mutagen	spontaneous
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	spontaneous (Peschel et al., 2006)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference The S220L substitution is within an 'LRR' domain. (Koh et al., 2006) Amino acid replacement: S220L. (Koh et al., 2006) Amino acid replacement: S?L. (Koh et al., 2006) Nucleotide substitution: C?T. (Koh et al., 2006)
Cytology
Phenotypic Data
Phenotypic Class
	photoperiod response variant (Koh et al., 2006)
Phenotype Manifest In

Detailed Description
	Statement Reference jet^r mutants can be trained to light:dark LD cycles, but take longer to be re-entrained to a new schedule than wild-type flies. The behaviour of these mutant flies within LD and constant darkness is not different to wild-type flies. While few wild-type flies show rhythmic behaviour in constant light conditions, jet^r, jet^r/jet^c, jet^r/Df(2L)Exel8012 and jet^r/Df(2L)Exel7021 mutants all show rhythmic behaviour under these conditions. Additionally, jet^r mutants show reduced responses to light pulses compared to wild-type flies. (Koh et al., 2006)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially rescued by	jet^r is partially rescued by jet^Scer\UAS.cKa/Scer\GAL4^cry.PU (Koh et al., 2006) jet^r is partially rescued by Scer\GAL4^tim.PE/jet^Scer\UAS.cKa (Koh et al., 2006)
Comments	Expression of the jet[Scer\UAS.cKa] transgene, under the control of either Scer\GAL4[cry.PU] or Scer\GAL4[tim.PE], partially rescues the reduced light response phenotype of jet[r] mutants. (Koh et al., 2006)
Stocks ( 1 )
Bloomington	27641 y¹ w^*; jet^r
Notes on Origin
Discoverer

Comments
	The stability of the jet protein is reduced in jet^r mutants. (Koh et al., 2006)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	jet^r (Koh et al., 2006, Koh et al., 2006, Peschel et al., 2006, Chen et al., 2011)
Name Synonym	rare (Van Gelder, 2006)
Secondary FlyBase IDs

References ( 5 )
Research paper	Chen et al., 2011, Curr. Biol. 21(9): 719--729 QUASIMODO, a Novel GPI-Anchored Zona Pellucida Protein Involved in Light Input to the Drosophila Circadian Clock. [FBrf0213611] Koh et al., 2006, Science 312(5781): 1809--1812 JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS. [FBrf0193019] Peschel et al., 2006, Proc. Natl. Acad. Sci. U.S.A. 103(46): 17313--17318 Veela defines a molecular link between Cryptochrome and Timeless in the light-input pathway to Drosophila's circadian clock. [FBrf0192726]
Supplementary material	Koh et al., 2006, Science 312(5781): Supporting online material for "Jetlag resets the Drosophila circadian clock by promoting light-induced degradation of timeless". [FBrf0199181]
Review	Van Gelder, 2006, Proc. Natl. Acad. Sci. U.S.A. 103(47): 17583--17584 Timeless genes and jetlag. [FBrf0193580]

Allele Dmel\jetr

Allele Dmel\jet^r