Allele Dmel\santa-maria¹

General Information
Symbol	Dmel\santa-maria¹	Species	D. melanogaster
Name		FlyBase ID	FBal0196218
Feature type	allele	Associated gene	Dmel\santa-maria
Also Known As	santa maria¹

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Wang et al., 2007)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Nucleotide substitution: G?A. (Wang et al., 2007) Amino acid replacement: G217D. (Wang et al., 2007)
Cytology
Phenotypic Data
Phenotypic Class
	auditory perception defective \| adult stage (Senthilan et al., 2012) neurophysiology defective (Wang et al., 2007) neurophysiology defective \| adult stage (Senthilan et al., 2012) thermotaxis behavior defective \| larval stage (Shen et al., 2011) viable (Wang et al., 2007)
Phenotype Manifest In

Detailed Description
	Statement Reference Mechanical and electrical responses to sound in the Johnston's organ are impaired in mutant flies. (Senthilan et al., 2012) Mutant larvae show defects in discrimination between 18[o]C and 24[o]C in a binary choice thermotaxis assay compared to controls. This defect is reversed if all trans-retinal is added to the food. (Shen et al., 2011) Electroretinograms from santa-maria¹ flies fail to show prolonged depolarization afterpotential (PDA) in response to blue light. This phenotype is rescued when flies are fed with all-trans-retinal but not when they are fed with β-carotene. (Wang et al., 2007)
External Data
Linkouts
Interactions
Phenotypic Class
NOT suppressed by
Statement Reference santa-maria¹ has neurophysiology defective phenotype, non-suppressible by Scer\GAL4^{santa-maria.PW}/Hsap\SCARB1^Scer\UAS.cWa (Wang et al., 2007) santa-maria¹ has neurophysiology defective phenotype, non-suppressible by Scer\GAL4^{santa-maria.PW}/ninaD^Scer\UAS.cKa (Wang et al., 2007)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	santa-maria¹ is rescued by santa-maria^Scer\UAS.cWa/Scer\GAL4^elav.PLu (Wang et al., 2007) santa-maria¹ is rescued by santa-maria^Scer\UAS.cWa/Scer\GAL4^ph-p-NP0761 (Senthilan et al., 2012) santa-maria¹ is rescued by Scer\GAL4^ninaB.PW/santa-maria^Scer\UAS.cWa (Wang et al., 2007) santa-maria¹ is rescued by Scer\GAL4^repo/santa-maria^Scer\UAS.cWa (Wang et al., 2007) santa-maria¹ is rescued by Scer\GAL4^{santa-maria.PW}/santa-maria^Scer\UAS.cWa (Wang et al., 2007)
Partially rescued by	santa-maria¹ is partially rescued by santa-maria^hs.PW (Wang et al., 2007)
Not rescued by	santa-maria¹ is not rescued by Scer\GAL4^drm.7.1/santa-maria^Scer\UAS.cWa (Wang et al., 2007) santa-maria¹ is not rescued by Scer\GAL4^ninaD.PW/santa-maria^Scer\UAS.cWa (Wang et al., 2007) santa-maria¹ is not rescued by Scer\GAL4^ninaE.PD/santa-maria^Scer\UAS.cWa (Wang et al., 2007) santa-maria¹ is not rescued by Scer\GAL4^rdhB.PW/santa-maria^Scer\UAS.cWa (Wang et al., 2007)
Comments	Expression of santa-maria[Scer\UAS.cWa] under the control of Scer\GAL4[ph-p-NP0761] rescues the defects in mechanical and electrical responses of the Johnston's organ to sound which are seen in santa-maria[1] flies. (Senthilan et al., 2012) Expression of santa-maria^hs.PW restores a prolonged depolarization afterpotential in response to blue light in electroretinogram recordings from santa-maria¹ flies. (Wang et al., 2007)
Stocks ( 2 )
Bloomington	24520 w^; santa-maria¹ 24519 w^; santa-maria¹; P{UAS-santa-maria.W}3
Notes on Origin
Discoverer
	Selected as: a homozygous viable mutation that causes a defect in electroretinogram recordings in a screen of chromosome 2. (Wang et al., 2007)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	santa-maria¹ (Senthilan et al., 2012) santa maria¹ (Wang et al., 2007, Shen et al., 2011)
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Senthilan et al., 2012, Cell 150(5): 1042--1054 Drosophila auditory organ genes and genetic hearing defects. [FBrf0219321] Shen et al., 2011, Science 331(6022): 1333--1336 Function of rhodopsin in temperature discrimination in Drosophila. [FBrf0213227] Wang et al., 2007, J. Cell Biol. 177(2): 305--316 Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction. [FBrf0199300]

Allele Dmel\santa-maria1

Allele Dmel\santa-maria¹