Open Close
General Information
Symbol
Hsap\ATN1N917.65Q.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0196231
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of the first 917 amino acids of Hsap\ATN1 plus a 65 polyglutamine repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Hsap\ATN1N917.65Q.Scer\UAS under the control of Scer\GAL4GMR.PU results in progressive eye depigmentation and retinal collapse.

Expression of Hsap\ATN1N917.65Q.Scer\UAS in the glia (under the control of Scer\GAL4Eaat1.PR), or in the neurons (under the control of Scer\GAL4elav.PU), reduces animal viability.

The eyes of 4-day-old flies expressing Hsap\ATN1N917.65Q.Scer\UAS under the control of Scer\GAL4GMR.PF appear relatively normal, but after 15 days, eyes of this genotype show progressive pigment loss.

Expression of Hsap\ATN1N917.65Q.Scer\UAS under the control of either Scer\GAL4GMR.PF (leaky activity in wing tissue) or Scer\GAL4Bx-MS1096 induces ectopic wing vein differentiation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

The ectopic wing vein phenotype seen when Hsap\ATN1N917.65Q.Scer\UAS is expressed under the control of Scer\GAL4GMR.PF is enhanced in styΔ5, rlSem and Gug1207D6 heterozygotes.

The ectopic wing vein phenotype of Scer\GAL4GMR.PF>Hsap\ATN1N917.65Q.Scer\UAS flies is suppressed when either EgfrDN.Scer\UAS or GugUbi-p63E.T:Avic\GFP is coexpressed.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Hsap\ATN1N917.65Q.Scer\UAS
Hsap\ATN1N917.65Q.UAS
Name Synonyms
Secondary FlyBase IDs
    References (3)