Allele Hsap\ATN1^{N917.65Q.Scer\UAS}

General Information
Symbol	Hsap\ATN1^{N917.65Q.Scer\UAS}	Species	H. sapiens
Name		FlyBase ID	FBal0196231
Feature type	allele	Associated gene	Hsap\ATN1

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - deletion, in vitro construct - coding region fusion
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Charroux et al., 2006) in vitro construct - deletion (Charroux et al., 2006) in vitro construct - regulatory fusion (Charroux et al., 2006)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of the first 917 amino acids of Hsap\ATN1 plus a 26 polyglutamine repeat. (Charroux et al., 2006)
Carried in construct	P{UAS-ATN1.N917.65Q} (Charroux et al., 2006, Nisoli et al., 2010)
Cytology
Phenotypic Data
Phenotypic Class
	lethal, with Scer\GAL4^Eaat1.PR (Nisoli et al., 2010) lethal, with Scer\GAL4^elav.PU (Nisoli et al., 2010)
Phenotype Manifest In
	eye, with Scer\GAL4^GMR.PU (Nisoli et al., 2010) pigment cell, with Scer\GAL4^GMR.PF (Charroux et al., 2006) wing vein \| ectopic, with Scer\GAL4^Bx-MS1096 (Charroux et al., 2006) wing vein \| ectopic, with Scer\GAL4^GMR.PF (Charroux et al., 2006)
Detailed Description
	Statement Reference Expression of Hsap\ATN1[N917.65Q.Scer\UAS] under the control of Scer\GAL4[GMR.PU] results in progressive eye depigmentation and retinal collapse. Expression of Hsap\ATN1[N917.65Q.Scer\UAS] in the glia (under the control of Scer\GAL4[Eaat1.PR]), or in the neurons (under the control of Scer\GAL4[elav.PU]), reduces animal viability. (Nisoli et al., 2010) The eyes of 4-day-old flies expressing Hsap\ATN1^{N917.65Q.Scer\UAS} under the control of Scer\GAL4^GMR.PF appear relatively normal, but after 15 days, eyes of this genotype show progressive pigment loss. Expression of Hsap\ATN1^{N917.65Q.Scer\UAS} under the control of either Scer\GAL4^GMR.PF (leaky activity in wing tissue) or Scer\GAL4^Bx-MS1096 induces ectopic wing vein differentiation. (Charroux et al., 2006)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement Reference Hsap\ATN1^{N917.65Q.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has wing vein \| ectopic phenotype, enhanceable by Gug^1207D6/Gug[+] (Charroux et al., 2006) Hsap\ATN1^{N917.65Q.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has wing vein \| ectopic phenotype, enhanceable by rl[+]/rl^Sem (Charroux et al., 2006) Hsap\ATN1^{N917.65Q.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has wing vein \| ectopic phenotype, enhanceable by sty[+]/sty^Δ5 (Charroux et al., 2006)
Suppressed by
Statement Reference Hsap\ATN1^{N917.65Q.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has wing vein \| ectopic phenotype, suppressible by Egfr^DN.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Charroux et al., 2006) Hsap\ATN1^{N917.65Q.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has wing vein \| ectopic phenotype, suppressible by Gug^{Ubi-p63E.T:Avic\GFP}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Charroux et al., 2006)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference The ectopic wing vein phenotype seen when Hsap\ATN1^{N917.65Q.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF is enhanced in sty^Δ5, rl^Sem and Gug^1207D6 heterozygotes. The ectopic wing vein phenotype of Scer\GAL4^GMR.PF>Hsap\ATN1^{N917.65Q.Scer\UAS} flies is suppressed when either Egfr^DN.Scer\UAS or Gug^{Ubi-p63E.T:Avic\GFP} is coexpressed. (Charroux et al., 2006)
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Hsap\ATN1^{N917.65Q.Scer\UAS}
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Nisoli et al., 2010, Cell Death Differ. 17(10): 1577--1587 Neurodegeneration by polyglutamine Atrophin is not rescued by induction of autophagy. [FBrf0212035] Charroux et al., 2006, Dev. Biol. 291(2): 278--290 Atrophin contributes to the negative regulation of epidermal growth factor receptor signaling in Drosophila. [FBrf0190100]

Allele Hsap\ATN1N917.65Q.Scer\UAS

Allele Hsap\ATN1^{N917.65Q.Scer\UAS}