Allele Hsap\PINK1^{Scer\UAS.T:Zzzz\FLAG}

General Information
Symbol	Hsap\PINK1^{Scer\UAS.T:Zzzz\FLAG}	Species	H. sapiens
Name		FlyBase ID	FBal0196253
Feature type	allele	Associated gene	Hsap\PINK1

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - coding region fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Wang et al., 2006) in vitro construct - regulatory fusion (Wang et al., 2006)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS sequences drive expression of a cDNA encoding the entire coding sequence of wild type Hsap\PINK1 with a C-terminal T:Zzzz\FLAG tag. (Wang et al., 2006)
Carried in construct	P{UAS-PINK1.FLAG} (Wang et al., 2006)
Tagged with	T:Zzzz\FLAG (Wang et al., 2006)
Cytology
Phenotypic Data
Phenotypic Class
	chemical resistant, with Scer\GAL4^da.G32 (Wang et al., 2006)
Phenotype Manifest In

Detailed Description
	Statement Reference Flies overexpressing Hsap\PINK1^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^da.G32 show reduced sensitivity to treatment with paraquat or H₂O₂ but not 2-mercaptoethanol. (Wang et al., 2006)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Hsap\PINK1^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^da.G32 is a suppressor of lethal phenotype of Pink1^{dsRNA.Scer\UAS.cWa}, Scer\GAL4^da.G32 (Wang et al., 2006) Hsap\PINK1^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^Ddc.PL is a suppressor of neuroanatomy defective phenotype of Pink1^{dsRNA.Scer\UAS.cWa}, Scer\GAL4^Ddc.PL (Wang et al., 2006) Hsap\PINK1^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^elav.PLu is a suppressor of neuroanatomy defective phenotype of Pink1^{dsRNA.Scer\UAS.cWa}, Scer\GAL4^elav.PLu (Wang et al., 2006) Hsap\PINK1^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Pink1^{dsRNA.Scer\UAS.cWa}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Wang et al., 2006)
Phenotype Manifest In
Suppressor of
Statement Reference Hsap\PINK1^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^Ddc.PL is a suppressor of dopamine neuron & adult brain phenotype of Pink1^{dsRNA.Scer\UAS.cWa}, Scer\GAL4^Ddc.PL (Wang et al., 2006) Hsap\PINK1^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^elav.PLu is a suppressor of dopamine neuron & adult brain phenotype of Pink1^{dsRNA.Scer\UAS.cWa}, Scer\GAL4^elav.PLu (Wang et al., 2006) Hsap\PINK1^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Pink1^{dsRNA.Scer\UAS.cWa}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Wang et al., 2006) Hsap\PINK1^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a suppressor of ommatidium phenotype of Pink1^{dsRNA.Scer\UAS.cWa}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Wang et al., 2006)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Hsap\PINK1^{Scer\UAS.T:Zzzz\FLAG}
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Wang et al., 2006, Proc. Natl. Acad. Sci. U.S.A. 103(36): 13520--13525 Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila. [FBrf0192173]

Allele Hsap\PINK1Scer\UAS.T:Zzzz\FLAG

Allele Hsap\PINK1^{Scer\UAS.T:Zzzz\FLAG}