Adults co-expressing Hsap\ATXN3fl.Q84.UAS.Tag:MYC together with either Cul1GD9650 or FipoQNIG.2010R, under the control of Scer\GAL4GMR.PU, display mild eye depigmentation; this phenotype is not further enhanced by the triple co-expression of Hsap\ATXN3fl.Q84.UAS.Tag:MYC, Cul1GD9650 and FipoQNIG.2010R.
Reduction of Cdk5 transcript abundance, through the expression of Cdk5GD13840 in eyes expressing Hsap\ATXN3fl.Q84.Scer\UAS.T:Hsap\MYC (all transgenes under the control of Scer\GAL4GMR.long) causes a disturbed eye surface and a loss of pigmentation.
RNAi-mediated Cdk5 reduction in Hsap\ATXN3fl.Q84.Scer\UAS.T:Hsap\MYC-expressing flies (under the control of Scer\GAL4elav-C155) results in an almost 50% reduction of median survival compared to controls.
Co-expression of embNIG.13387R enhances the loss of rhabdomere phenotype caused by expression of Hsap\MJDfl.Q84.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4GMR.PF. This enhancement is suppressed by co-expression of Hsap\HSPA1LScer\UAS.cWa.
Co-expression of Atx2Scer\UAS.cSa and Hsap\ATXN3fl.Q84.Scer\UAS.T:Hsap\MYC in differentiated photoreceptor neurons under the control of Scer\GAL4ninaE.PD enhances the visible photoreceptor loss seen when either construct is expressed alone. At 18-23 days only 2.9 photoreceptors are seen per ommatidium, as opposed to the seven seen in wild type. This compares to 6.3 and 6.97 in Atx2Scer\UAS.cSa and Hsap\ATXN3fl.Q84.Scer\UAS.T:Hsap\MYC respectively.
Eye degeneration due to expression of Hsap\MJDfl.Q84.Scer\UAS.T:Hsap\MYC in the eye (under the control of Scer\GAL4GMR.PF) is enhanced in a loqsf00791 background, resulting in dramatically reduced retinal thickness.