Allele Dmel\shrb^Scer\UAS.cSa

General Information
Symbol	Dmel\shrb^Scer\UAS.cSa	Species	D. melanogaster
Name		FlyBase ID	FBal0196634
Feature type	allele	Associated gene	Dmel\shrb

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Sweeney et al., 2006, Sweeney et al., 2006)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of shrb coding sequences. (Sweeney et al., 2006, Sweeney et al., 2006)
Carried in construct	P{UAS-shrb.S} (Sweeney et al., 2006, Sweeney et al., 2006)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference Expression of shrb^Scer\UAS.cSa under the control of Scer\GAL4²²¹ does not generate a branching phenotype different to that in wild-type. (Sweeney et al., 2006)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	Scer\GAL4^109(2)80/shrb^Scer\UAS.cSa rescues shrb⁴ (Sweeney et al., 2006) shrb^Scer\UAS.cSa/Scer\GAL4^αTub84B.PL rescues shrb⁴ (Sweeney et al., 2006)
Comments	Rescue of shrb⁴ embryonic lethality with shrb^Scer\UAS.cSa, under the control of Scer\GAL4^αTub84B.PL allows survival of 99% of mutant embryos to the third instar larval stage. Expression of two copies of shrb^Scer\UAS.cSa in neurons of the peripheral nervous system, under the control of Scer\GAL4^109(2)80, rescues the average dendritic field size of dorsal cluster DA neurons in shrb⁴ mutants to near wild-type levels. The rescued dorsal clusters contain a number of lateral branches that are largely absent in shrb⁴ mutant clusters (Sweeney et al., 2006)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	shrb^Scer\UAS.cSa
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Sweeney et al., 2006, Curr. Biol. 16(10): 1006--1011 The coiled-coil protein shrub controls neuronal morphogenesis in Drosophila. [FBrf0199197]
Supplementary material	Sweeney et al., 2006, Curr. Biol. 16(10): The coiled-coil protein shrub controls neuronal morphogenesis in Drosophila. [FBrf0199198]

Allele Dmel\shrbScer\UAS.cSa

Allele Dmel\shrb^Scer\UAS.cSa