FlyBase Allele Report: Dmel\vvl[sep]

General Information

Symbol

Dmel\vvl^sep

Species

D. melanogaster

Name

FlyBase ID

FBal0196913

Feature type

allele

Associated gene

Dmel\vvl

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Certel et al., 2000, de Celis et al., 1995)

Mutagen

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Caused by aberration

In(3LR)sep

Cytology

Nature of the lesion

Statement

Reference

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(de Celis et al., 1995)

visible (with Df(3L)XBB70)

(Certel et al., 2000)

visible (with TM3)

(Miller et al., 2020)

Phenotype Manifest In

posterior crossvein

(Lindsley and Zimm, 1992)

posterior crossvein (with Df(3L)XBB70)

(Certel et al., 2000)

wing (with Df(3L)XBB70)

(Certel et al., 2000)

wing vein (with Df(3L)XBB70)

(Certel et al., 2000)

wing vein (with TM3)

(Miller et al., 2020)

wing vein L2 (with Df(3L)XBB70)

(Certel et al., 2000)

wing vein L4

(de Celis et al., 1995)

wing vein L4 (with Df(3L)XBB70)

(Certel et al., 2000)

Detailed Description

Statement

Reference

vvl^sep/Df(3L)XBB70 flies will eclose as adults but cannot be maintained as a viable stock. The adults show a reduction in wing size to 75-80% of normal with disruptions in wing vein patterning. Wings consistently show incomplete posterior crossvein formation as well as thinning or breaks in veins L2 and L4.

(Certel et al., 2000)

vvl^Zm/vvl^sep adults has a wing phenotype that overlaps wild type, a fraction of mutant flies have small gaps in the LIV vein.

(de Celis et al., 1995)

Most of posterior crossvein absent, one-third usually remaining attached to vein L5. RK2A.

(Lindsley and Zimm, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Other

Statement

Reference

dpp^s1, vvl^sep/vvl^sep has wing vein L2 phenotype

(de Celis et al., 1995)

tkv¹/tkv⁷, vvl^sep/vvl^sep has wing vein L2 phenotype

(de Celis et al., 1995)

Egfr^f37/Egfr^t1, vvl^sep/vvl^sep has wing vein L2 phenotype

(de Celis et al., 1995)

Egfr^f37/Egfr^t1, vvl^sep/vvl^sep has wing vein L3 phenotype

(de Celis et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

In combination with dpp^s1 or tkv¹/tkv⁷, both LII and LIV are affected. The thick vein phenotype associated with tkv mutants is suppressed. The phenotype of vvl^Zm/vvl^sep is also enhanced by Egfr mutants, with all longitudinal veins except L3 disappearing. vvl^Zm/vvl^sep also enhances the loss of vein phenotypes associated with Ax mutations of N.