FlyBase Allele Report: Dmel\mir-278[EP2316]

General Information

Symbol

Dmel\mir-278^EP2316

Species

D. melanogaster

Name

FlyBase ID

FBal0196945

Feature type

allele

Associated gene

Dmel\mir-278

Associated Insertion(s)

P{EP}mir-278^EP2316

Carried in Construct

Also Known As

EP(2)2316

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Pena-Rangel et al., 2002, Gene Disruption Project members, 2001-, Abdelilah-Seyfried et al., 2000)

Progenitor genotype

Associated Insertion(s)

P{EP}mir-278^EP2316

Cytology

Description

A P{EP} insertion upstream of the mir-278 locus, in the correct orientation to drive overexpression of mir-278.

(Nairz et al., 2006)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:15,610,905..15,610,905 [+]

(Nairz et al., 2006, Pena-Rangel et al., 2002, Gene Disruption Project members, 2001-, Abdelilah-Seyfried et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number, with Scer\GAL4^GMR.PF

(Nairz et al., 2006)

visible, with Scer\GAL4^GMR.PF

(Müller et al., 2005)

visible, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of mir-278^EP2316, driven by Scer\GAL4^GMR.PF, leads to overgrowth in the eye.

(Nairz et al., 2006)

Expression of EP1229^EP2316 under the control of Scer\GAL4^GMR.PF results in large, rough eyes.

(Müller et al., 2005)

Expression of EP1229^EP2316 under the control of Scer\GAL4^sca-537.4 results in too many or too few scutellar and dorsocentral macrochaetae. Sensory organs with no socket and one shaft and abnormal shaft morphology are seen.

(Abdelilah-Seyfried et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^sca-537.4, mir-278^EP2316 has visible phenotype, non-enhanceable by N[+]/N^55e11

(Abdelilah-Seyfried et al., 2000)

NOT suppressed by

Statement

Reference

Scer\GAL4^sca-537.4, mir-278^EP2316 has visible phenotype, non-suppressible by N[+]/N^55e11

(Abdelilah-Seyfried et al., 2000)

Enhancer of

Statement

Reference

mir-278^EP2316/Scer\GAL4^pnr-MD237 is an enhancer of visible phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

Suppressor of

Statement

Reference

mir-278^EP2316/Scer\GAL4^GMR.PF is a suppressor | partially of visible phenotype of p53^GMR.Ex

(Müller et al., 2005)

mir-278^EP2316/Scer\GAL4^GMR.PF is a suppressor of visible phenotype of hid^GMR.PG

(Müller et al., 2005)

mir-278^EP2316/Scer\GAL4^GMR.PF is a suppressor of visible phenotype of grim^GMR.PC

(Müller et al., 2005)

mir-278^EP2316/Scer\GAL4^GMR.PF is a suppressor of visible phenotype of rpr^GMR.PW

(Müller et al., 2005)

Phenotype Manifest In

Enhancer of

Statement

Reference

mir-278^EP2316/Scer\GAL4^pnr-MD237 is an enhancer of chaeta phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

NOT Enhancer of

Statement

Reference

mir-278^EP2316/Scer\GAL4^sca-537.4 is a non-enhancer of phenotype of N^55e11

(Abdelilah-Seyfried et al., 2000)

Suppressor of

Statement

Reference

mir-278^EP2316/Scer\GAL4^GMR.PF is a suppressor | partially of eye phenotype of p53^GMR.Ex

(Müller et al., 2005)

mir-278^EP2316/Scer\GAL4^GMR.PF is a suppressor of eye phenotype of hid^GMR.PG

(Müller et al., 2005)

mir-278^EP2316/Scer\GAL4^GMR.PF is a suppressor of eye phenotype of grim^GMR.PC

(Müller et al., 2005)

mir-278^EP2316/Scer\GAL4^GMR.PF is a suppressor of eye phenotype of rpr^GMR.PW

(Müller et al., 2005)

Other

Statement

Reference

Scer\GAL4^pnr-MD237, mir-278^EP2316, pnr^MD237 has scutellum phenotype

(Pena-Rangel et al., 2002)

Scer\GAL4^pnr-MD237, mir-278^EP2316, pnr^MD237 has adult head phenotype

(Pena-Rangel et al., 2002)

Scer\GAL4^pnr-MD237, mir-278^EP2316, pnr^MD237 has scutellar bristle phenotype

(Pena-Rangel et al., 2002)

Scer\GAL4^pnr-MD237, mir-278^EP2316, pnr^MD237/pnr[+] has scutellum phenotype

(Pena-Rangel et al., 2002)

Scer\GAL4^pnr-MD237, mir-278^EP2316, pnr^MD237/pnr[+] has adult head phenotype

(Pena-Rangel et al., 2002)

Scer\GAL4^pnr-MD237, mir-278^EP2316, pnr^MD237/pnr[+] has scutellar bristle phenotype

(Pena-Rangel et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

pnr^MD237/+ adults expressing EP1229^EP2316 under the control of Scer\GAL4^pnr-MD237 have a slightly deformed head and scutellum and show loss of scutellar macrochaetae.

(Pena-Rangel et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a P{EP} insertion line that modifies the pnr^MD237/+ phenotype when expressed using Scer\GAL4^pnr-MD237.

(Pena-Rangel et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

EP(2)2316

(Müller et al., 2005, Abdelilah-Seyfried et al., 2000)

EP1229^EP2316

EP2316^EP2316

mir-278^EP2316

Name Synonyms

Secondary FlyBase IDs

FBal0119641
FBal0195442

References (6)

Report Sections

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