FB2025_01 , released February 20, 2025
Allele: Dmel\lazaEY04417
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General Information
Symbol
Dmel\lazaEY04417
Species
D. melanogaster
Name
FlyBase ID
FBal0196948
Feature type
allele
Associated gene
Dmel\laza
Associated Insertion(s)
P{EPgy2}lazaEY04417
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}lazaEY04417
Cytology
Description

The element P{EPgy2}lazaEY04417 is inserted in the 5'untranslated region 309 base pairs upstream of the translation initiation site.

(Kwon and Montell, 2006)
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      lazaEY04417 mutant eyes display aberrant phototransduction. Exposure of wild-type flies to light results in a corneal negative receptor potential, which decays to baseline after cessation of the light stimulus. The amplitude of the light response is reduced nearly 40% in lazaEY04417 flies. A reduction in the amplitude of the light response is also observed in lazaEY04417/Df(3L)ED230 flies. The decreased phototransduction response in lazaEY04417 flies is not age dependent.

      (Kwon and Montell, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      lazaEY04417 is rescued by laza+t10.35

      (Kwon and Montell, 2006)
      Comments

      Expression of laza+t.10.35kb in a lazaEY04417 background rescues the phototransduction response.

      (Kwon and Montell, 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CG11440EY04417
      lazaEY04417
      lazaGE
      (Kwon and Montell, 2006, Kwon and Montell, 2006)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0162562
      • FBal0196199
      References (5)